biostudies-literatureWang DNatural Science Foundation of Inner MongoliaDoctoral Start-up Fund Project of Inner Mongolia Medical UniversityKey Project of Inner Mongolia Medical UniversityNational Natural Science Foundation of ChinaFoundation of Inner Mongolia Medical University750https://www.ebi.ac.uk/biostudies/studies/S-EPMC12469758biostudies-literatureUnknown11(9)Hydroxyl radicals (·OH) offer exceptional potential for cancer treatment through reactive oxygen species (ROS) amplification and apoptotic induction. However, conventional Fe-based metal-organic framework (Fe-MOF) nanomaterials are limited by inadequate Fe²⁺ concentrations, resulting in suboptimal Fenton catalytic performance. This study presents concave octahedral Fe-MOF nanomaterials with integrated bimetallic Fe/Zn centers through controlled solvothermal synthesis. The nanoplatform exhibits high specific surface area (559 m²/g) and 5-fluorouracil (5-FU) loading efficiency (58.7%). These structural properties establish it as a potential nanobuilding block for constructing stimuli-responsive gels. With optimized Fe²⁺ content (57.3%), the Fe-MOF material shGels (Basel, Switzerland)Concave-Octahedral Fe<sup>2+</sup>-Rich Fe-MOF/FU Nano-Blocks with Enhanced pH-Responsive Nanozyme Activity Toward Stimuli-Responsive Gels for Chemo-Chemodynamic Synergistic Therapy.PMC1246975882360824YKD2025ZD009YKD2025BSQD022, YKD2024BSQD0092024QN05006YKD2023MS082Bao LQi HGuo HWang DCheng RWu SXu CWang LfalseConcave-Octahedral Fe<sup>2+</sup>-Rich Fe-MOF/FU Nano-Blocks with Enhanced pH-Responsive Nanozyme Activity Toward Stimuli-Responsive Gels for Chemo-Chemodynamic Synergistic Therapy.Hydroxyl radicals (·OH) offer exceptional potential for cancer treatment through reactive oxygen species (ROS) amplification and apoptotic induction. However, conventional Fe-based metal-organic framework (Fe-MOF) nanomaterials are limited by inadequate Fe²⁺ concentrations, resulting in suboptimal Fenton catalytic performance. This study presents concave octahedral Fe-MOF nanomaterials with integrated bimetallic Fe/Zn centers through controlled solvothermal synthesis. The nanoplatform exhibits high specific surface area (559 m²/g) and 5-fluorouracil (5-FU) loading efficiency (58.7%). These structural properties establish it as a potential nanobuilding block for constructing stimuli-responsive gels. With optimized Fe²⁺ content (57.3%), the Fe-MOF material sh2025-01-01T00:00:00Z2025 Sep2026-05-01T03:23:30.696Z2026-05-01T03:11:23.731ZS-EPMC124697584100252410.3390/gels11090750