{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Opperman RM"],"funding":["NATIONAL SCIENCE AND ENGINEERING RESEARCH COUNCIL OF CANADA","CANADA FOUNDATION FOR INNOVATION JOHN R. EVANS LEADER FUND","LOTTE AND JOHN HECHT MEMORIAL FOUNDATION","RESEARCH MANITOBA","CANADA RESEARCH CHAIR PROGRAM","BREAST CANCER CANADA"],"pagination":["9103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12470079"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(18)"],"pubmed_abstract":["Oxidative stress has a dual role in breast cancer, promoting growth at moderate levels while causing cell death at higher levels, such as during therapeutic interventions that increase reactive oxygen species production. Oncogenic microRNAs miR-526b and miR-655 promote aggressive cancer traits-such as proliferation, migration, invasion, hypoxia response, cancer stem cell properties, and metastasis-via COX-2/EP4/PI3K pathways. These miRNAs and oxidative stress appear to engage in a self-amplifying loop, where miRNA overexpression increases ROS levels, and moderate oxidative stress, in turn, enhances miRNA expression-although the mechanisms are not yet fully understood. This study investigates how overexpressing miR-526b, miR-655, and COX-2 influences breast cancer cell responses to oxidativ"],"journal":["International journal of molecular sciences"],"pubmed_title":["Distinct Oxidative Stress Adaptations Driven by the Overexpression of miR-526b, miR-655, and COX-2 in Breast Cancer."],"pmcid":["PMC12470079"],"funding_grant_id":["RGPIN-2017-04787","39674","950 - 232738","4851","2022-004","4885"],"pubmed_authors":["Opperman RM","Majumder M","Maiti S"],"additional_accession":[]},"is_claimable":false,"name":"Distinct Oxidative Stress Adaptations Driven by the Overexpression of miR-526b, miR-655, and COX-2 in Breast Cancer.","description":"Oxidative stress has a dual role in breast cancer, promoting growth at moderate levels while causing cell death at higher levels, such as during therapeutic interventions that increase reactive oxygen species production. Oncogenic microRNAs miR-526b and miR-655 promote aggressive cancer traits-such as proliferation, migration, invasion, hypoxia response, cancer stem cell properties, and metastasis-via COX-2/EP4/PI3K pathways. These miRNAs and oxidative stress appear to engage in a self-amplifying loop, where miRNA overexpression increases ROS levels, and moderate oxidative stress, in turn, enhances miRNA expression-although the mechanisms are not yet fully understood. This study investigates how overexpressing miR-526b, miR-655, and COX-2 influences breast cancer cell responses to oxidativ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-07-04T03:15:18.274Z","creation":"2026-07-04T03:12:57.973Z"},"accession":"S-EPMC12470079","cross_references":{"pubmed":["41009689"],"doi":["10.3390/ijms26189103"]}}