{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["AlAbdullatif A"],"funding":["Research, Development, and Innovation \" Authority (RDIA) - Kingdom of Saudi Arabia"],"pagination":["1349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12472914"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(9)"],"pubmed_abstract":["<b>Background/Objectives:</b> Cervical cancer remains a major health challenge, especially in low-resource regions with limited diagnostic and advanced treatment options. Nanotechnology-based strategies offer promising alternatives to conventional chemotherapy by reducing systemic toxicity and enabling site-specific delivery. <b>Methods:</b> In this study, halloysite (Hall) was functionalized with green-synthesized 2 wt% zinc oxide (GZn) and silver (GAg) nanoparticles (NPs) using <i>Tribulus terrestris</i> extract (25 mM) to enhance cisplatin (Cp) and carboplatin (Cbpt) delivery for targeted cervical cancer therapy. <b>Results:</b> Structural and morphological analyses confirmed the successful integration of GZn and GAg NPs into the Hall without compromising its tubular integrity. Cp or Cb"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["&lt;i&gt;Tribulus terrestris&lt;/i&gt;-Mediated ZnO/Ag-Halloysite Nanohybrids for Targeted Cisplatin and Carboplatin Delivery in Cervical Cancer Treatment."],"pmcid":["PMC12472914"],"funding_grant_id":["12968-iau-2023-iau-R-3-1-HW-"],"pubmed_authors":["AlAbdullatif A","Jermy BR","Dafalla H","Almofty S","Tanimu G","Alahmari F"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Tribulus terrestris&lt;/i&gt;-Mediated ZnO/Ag-Halloysite Nanohybrids for Targeted Cisplatin and Carboplatin Delivery in Cervical Cancer Treatment.","description":"<b>Background/Objectives:</b> Cervical cancer remains a major health challenge, especially in low-resource regions with limited diagnostic and advanced treatment options. Nanotechnology-based strategies offer promising alternatives to conventional chemotherapy by reducing systemic toxicity and enabling site-specific delivery. <b>Methods:</b> In this study, halloysite (Hall) was functionalized with green-synthesized 2 wt% zinc oxide (GZn) and silver (GAg) nanoparticles (NPs) using <i>Tribulus terrestris</i> extract (25 mM) to enhance cisplatin (Cp) and carboplatin (Cbpt) delivery for targeted cervical cancer therapy. <b>Results:</b> Structural and morphological analyses confirmed the successful integration of GZn and GAg NPs into the Hall without compromising its tubular integrity. Cp or Cb","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T03:19:37.353Z","creation":"2026-06-02T03:12:01.855Z"},"accession":"S-EPMC12472914","cross_references":{"pubmed":["41011218"],"doi":["10.3390/ph18091349"]}}