biostudies-literatureAlAbdullatif AResearch, Development, and Innovation " Authority (RDIA) - Kingdom of Saudi Arabia1349https://www.ebi.ac.uk/biostudies/studies/S-EPMC12472914biostudies-literatureUnknown18(9)<b>Background/Objectives:</b> Cervical cancer remains a major health challenge, especially in low-resource regions with limited diagnostic and advanced treatment options. Nanotechnology-based strategies offer promising alternatives to conventional chemotherapy by reducing systemic toxicity and enabling site-specific delivery. <b>Methods:</b> In this study, halloysite (Hall) was functionalized with green-synthesized 2 wt% zinc oxide (GZn) and silver (GAg) nanoparticles (NPs) using <i>Tribulus terrestris</i> extract (25 mM) to enhance cisplatin (Cp) and carboplatin (Cbpt) delivery for targeted cervical cancer therapy. <b>Results:</b> Structural and morphological analyses confirmed the successful integration of GZn and GAg NPs into the Hall without compromising its tubular integrity. Cp or CbPharmaceuticals (Basel, Switzerland)<i>Tribulus terrestris</i>-Mediated ZnO/Ag-Halloysite Nanohybrids for Targeted Cisplatin and Carboplatin Delivery in Cervical Cancer Treatment.PMC1247291412968-iau-2023-iau-R-3-1-HW-AlAbdullatif AJermy BRDafalla HAlmofty STanimu GAlahmari Ffalse<i>Tribulus terrestris</i>-Mediated ZnO/Ag-Halloysite Nanohybrids for Targeted Cisplatin and Carboplatin Delivery in Cervical Cancer Treatment.<b>Background/Objectives:</b> Cervical cancer remains a major health challenge, especially in low-resource regions with limited diagnostic and advanced treatment options. Nanotechnology-based strategies offer promising alternatives to conventional chemotherapy by reducing systemic toxicity and enabling site-specific delivery. <b>Methods:</b> In this study, halloysite (Hall) was functionalized with green-synthesized 2 wt% zinc oxide (GZn) and silver (GAg) nanoparticles (NPs) using <i>Tribulus terrestris</i> extract (25 mM) to enhance cisplatin (Cp) and carboplatin (Cbpt) delivery for targeted cervical cancer therapy. <b>Results:</b> Structural and morphological analyses confirmed the successful integration of GZn and GAg NPs into the Hall without compromising its tubular integrity. Cp or Cb2025-01-01T00:00:00Z2025 Sep2026-06-02T03:19:37.353Z2026-06-02T03:12:01.855ZS-EPMC124729144101121810.3390/ph18091349