biostudies-literatureUnknown30(18)Bumaznik DThe UV-induced photolysis of 2-aminothiazole-4-carboxylic acid (ACA), a biologically active molecule, was studied using the infrared matrix isolation method. As the first step of photolysis, a decarboxylation reaction occurred. Subsequently, two main photolysis pathways of 2-aminothiazole were observed, during which a number of new molecules, including potential prebiotic carbodiimides or molecular complexes, were identified. The CS-CN bond cleavage path produced <i>N</i>-(1-sulfanylethen-2-yl)carbodiimide (fp1), <i>N</i>-(thiiran-2-yl)carbodiimide (fp3), <i>N</i>-(1-thioethan-2-yl)carbodiimide (fp2), <i>N</i>-(1-thioethan-1-yl)carbodiimide (fp4) and <i>N</i>-(1-thioethan-2-yl)cyanamide (fp33), which were identified for the first time. In this channel, additional disruption of the N-C bondMolecules (Basel, Switzerland)3713https://www.ebi.ac.uk/biostudies/studies/S-EPMC12472919biostudies-literatureUV-Induced Photodegradation of 2-Aminothiazole-4-Carboxylic Acid: Identification of New Carbodiimide Molecules.PMC12472919Bumaznik DSaldyka MfalseUV-Induced Photodegradation of 2-Aminothiazole-4-Carboxylic Acid: Identification of New Carbodiimide Molecules.The UV-induced photolysis of 2-aminothiazole-4-carboxylic acid (ACA), a biologically active molecule, was studied using the infrared matrix isolation method. As the first step of photolysis, a decarboxylation reaction occurred. Subsequently, two main photolysis pathways of 2-aminothiazole were observed, during which a number of new molecules, including potential prebiotic carbodiimides or molecular complexes, were identified. The CS-CN bond cleavage path produced <i>N</i>-(1-sulfanylethen-2-yl)carbodiimide (fp1), <i>N</i>-(thiiran-2-yl)carbodiimide (fp3), <i>N</i>-(1-thioethan-2-yl)carbodiimide (fp2), <i>N</i>-(1-thioethan-1-yl)carbodiimide (fp4) and <i>N</i>-(1-thioethan-2-yl)cyanamide (fp33), which were identified for the first time. In this channel, additional disruption of the N-C bond2025-01-01T00:00:00Z2025 Sep2026-05-02T03:16:29.547Z2026-05-02T03:11:13.281ZS-EPMC124729194101160410.3390/molecules30183713