{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li R"],"funding":["Zhongchen Ma","Yong Wang"],"pagination":["2031"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12472996"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(9)"],"pubmed_abstract":["<i>Mycoplasma bovis</i> (<i>M. bovis</i>) adheres to host cells and persists intracellularly, causing chronic inflammation and significant economic losses in the cattle industry. The role of host cell apoptosis in this host-pathogen interaction remains unclear. This study isolated and identified the <i>M. bovis</i> Xinjiang strain XJ01 from diseased cattle in China. XJ01 exhibited typical \"fried egg\" colony morphology, distinct biochemical characteristics, and a 1.02 Mb genome (29.33% GC content) encoding 939 genes, including 93 unique genes. Functional analysis under optimal infection conditions (MOI = 1000, 24 h) revealed that XJ01 induced significant apoptosis and reduced viability in bovine macrophages (BoMac). This was accompanied by mitochondrial homeostasis disruption, characterized"],"journal":["Microorganisms"],"pubmed_title":["&lt;i&gt;Mycoplasma bovis&lt;/i&gt; Infection Induces Apoptosis Through Gadd45/XIAP in Bovine Macrophages."],"pmcid":["PMC12472996"],"funding_grant_id":["RCZK202456","2024AB034"],"pubmed_authors":["Sheng J","Zhang H","Ma Z","Li R","Tang T","Chen C","Wang Y","Yu X"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Mycoplasma bovis&lt;/i&gt; Infection Induces Apoptosis Through Gadd45/XIAP in Bovine Macrophages.","description":"<i>Mycoplasma bovis</i> (<i>M. bovis</i>) adheres to host cells and persists intracellularly, causing chronic inflammation and significant economic losses in the cattle industry. The role of host cell apoptosis in this host-pathogen interaction remains unclear. This study isolated and identified the <i>M. bovis</i> Xinjiang strain XJ01 from diseased cattle in China. XJ01 exhibited typical \"fried egg\" colony morphology, distinct biochemical characteristics, and a 1.02 Mb genome (29.33% GC content) encoding 939 genes, including 93 unique genes. Functional analysis under optimal infection conditions (MOI = 1000, 24 h) revealed that XJ01 induced significant apoptosis and reduced viability in bovine macrophages (BoMac). This was accompanied by mitochondrial homeostasis disruption, characterized","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-02T03:21:33.098Z","creation":"2026-05-02T03:11:52.01Z"},"accession":"S-EPMC12472996","cross_references":{"pubmed":["41011363"],"doi":["10.3390/microorganisms13092031"]}}