{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(18)"],"submitter":["Lee MG"],"pubmed_abstract":["<b>Background:</b> Safe, microbiome-based interventions for autoimmune hyperthyroidism are lacking. We isolated the lactic acid bacterium NES-428 from kimchi and previously demonstrated that it shares 99% 16S-rRNA identity with <i>Lactobacillus brevis</i> reference strains, confirming NES-428 as a novel strain. Here we evaluated its immunomodulatory and anti-thyroid activity in cellular and murine models. <b>Methods:</b> Jurkat T cells (5 × 10<sup>6</sup>) were incubated with heat-killed NES-428 for 24 h and subsequently stimulated with phorbol 12-myristate 13-acetate/ionomycin (50 ng mL<sup>-1</sup>/1 µg mL<sup>-1</sup>) for 6 h; cytokine transcripts were quantified by qRT-PCR. Hyperthyroidism was induced in female BALB/c mice by three intramuscular injections of adenovirus-encoding human"],"journal":["Nutrients"],"pagination":["2967"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12473064"],"repository":["biostudies-literature"],"pubmed_title":["Immunomodulatory Effects of &lt;i&gt;Lactobacillus brevis&lt;/i&gt; NES-428 in a Hyperthyroidism Mouse Model: Potential Applications for Graves' Disease."],"pmcid":["PMC12473064"],"pubmed_authors":["Lee MG","Yun CW","Lee DH","Kang S","Koh J"],"additional_accession":[]},"is_claimable":false,"name":"Immunomodulatory Effects of &lt;i&gt;Lactobacillus brevis&lt;/i&gt; NES-428 in a Hyperthyroidism Mouse Model: Potential Applications for Graves' Disease.","description":"<b>Background:</b> Safe, microbiome-based interventions for autoimmune hyperthyroidism are lacking. We isolated the lactic acid bacterium NES-428 from kimchi and previously demonstrated that it shares 99% 16S-rRNA identity with <i>Lactobacillus brevis</i> reference strains, confirming NES-428 as a novel strain. Here we evaluated its immunomodulatory and anti-thyroid activity in cellular and murine models. <b>Methods:</b> Jurkat T cells (5 × 10<sup>6</sup>) were incubated with heat-killed NES-428 for 24 h and subsequently stimulated with phorbol 12-myristate 13-acetate/ionomycin (50 ng mL<sup>-1</sup>/1 µg mL<sup>-1</sup>) for 6 h; cytokine transcripts were quantified by qRT-PCR. Hyperthyroidism was induced in female BALB/c mice by three intramuscular injections of adenovirus-encoding human","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-02T03:20:02.335Z","creation":"2026-05-02T03:11:47.625Z"},"accession":"S-EPMC12473064","cross_references":{"pubmed":["41010493"],"doi":["10.3390/nu17182967"]}}