{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(9)"],"submitter":["Alghanem S"],"pubmed_abstract":["<b>Objectives</b>: This study evaluated the comfort of using silicone tubes installed in the oral cavity as a reservoir for a hydrogel that allows for a slow delivery of the active substance acting locally or systemically. <b>Methods</b>: Perforated silicone tubes 8 cm long with two internal diameters were used: T1 (1.5 mm) and T2 (2.4 mm). The reservoirs were filled with hydrogel placebo formulations: carbomer 1.5% (C), hydroxyethylcellulose 4% (HEC), or hydroxypropylmethylcellulose (hypromellose) 3% (HPMC). Physical parameters of the gel were determined with a viscometer and a texture analyzer. During 4 h of application, the volunteers reported sensory perceptions, and the rate of gel erosion was evaluated. The results were correlated with the viscosity, rheology, and dissolution rate of"],"journal":["Pharmaceutics"],"pagination":["1095"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12473675"],"repository":["biostudies-literature"],"pubmed_title":["Prolonged Gel Delivery to Oral Cavity from a Silicone Tube: In Vivo Assessment."],"pmcid":["PMC12473675"],"pubmed_authors":["Lampkowski M","Ordyniec-Kwasnica I","Sznitowska M","Alghanem S","Dziurkowska E"],"additional_accession":[]},"is_claimable":false,"name":"Prolonged Gel Delivery to Oral Cavity from a Silicone Tube: In Vivo Assessment.","description":"<b>Objectives</b>: This study evaluated the comfort of using silicone tubes installed in the oral cavity as a reservoir for a hydrogel that allows for a slow delivery of the active substance acting locally or systemically. <b>Methods</b>: Perforated silicone tubes 8 cm long with two internal diameters were used: T1 (1.5 mm) and T2 (2.4 mm). The reservoirs were filled with hydrogel placebo formulations: carbomer 1.5% (C), hydroxyethylcellulose 4% (HEC), or hydroxypropylmethylcellulose (hypromellose) 3% (HPMC). Physical parameters of the gel were determined with a viscometer and a texture analyzer. During 4 h of application, the volunteers reported sensory perceptions, and the rate of gel erosion was evaluated. The results were correlated with the viscosity, rheology, and dissolution rate of","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-02T03:19:47.972Z","creation":"2026-05-02T03:11:36.292Z"},"accession":"S-EPMC12473675","cross_references":{"pubmed":["41012434"],"doi":["10.3390/pharmaceutics17091095"]}}