biostudies-literatureUnknown17(9)Alghanem S<b>Objectives</b>: This study evaluated the comfort of using silicone tubes installed in the oral cavity as a reservoir for a hydrogel that allows for a slow delivery of the active substance acting locally or systemically. <b>Methods</b>: Perforated silicone tubes 8 cm long with two internal diameters were used: T1 (1.5 mm) and T2 (2.4 mm). The reservoirs were filled with hydrogel placebo formulations: carbomer 1.5% (C), hydroxyethylcellulose 4% (HEC), or hydroxypropylmethylcellulose (hypromellose) 3% (HPMC). Physical parameters of the gel were determined with a viscometer and a texture analyzer. During 4 h of application, the volunteers reported sensory perceptions, and the rate of gel erosion was evaluated. The results were correlated with the viscosity, rheology, and dissolution rate ofPharmaceutics1095https://www.ebi.ac.uk/biostudies/studies/S-EPMC12473675biostudies-literatureProlonged Gel Delivery to Oral Cavity from a Silicone Tube: In Vivo Assessment.PMC12473675Lampkowski MOrdyniec-Kwasnica ISznitowska MAlghanem SDziurkowska EfalseProlonged Gel Delivery to Oral Cavity from a Silicone Tube: In Vivo Assessment.<b>Objectives</b>: This study evaluated the comfort of using silicone tubes installed in the oral cavity as a reservoir for a hydrogel that allows for a slow delivery of the active substance acting locally or systemically. <b>Methods</b>: Perforated silicone tubes 8 cm long with two internal diameters were used: T1 (1.5 mm) and T2 (2.4 mm). The reservoirs were filled with hydrogel placebo formulations: carbomer 1.5% (C), hydroxyethylcellulose 4% (HEC), or hydroxypropylmethylcellulose (hypromellose) 3% (HPMC). Physical parameters of the gel were determined with a viscometer and a texture analyzer. During 4 h of application, the volunteers reported sensory perceptions, and the rate of gel erosion was evaluated. The results were correlated with the viscosity, rheology, and dissolution rate of2025-01-01T00:00:00Z2025 Aug2026-05-02T03:19:47.972Z2026-05-02T03:11:36.292ZS-EPMC124736754101243410.3390/pharmaceutics17091095