{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sharma V"],"funding":["Department of Science and Technology, Chandigarh Administration, India"],"pagination":["1710"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12474774"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Aim</h4>Pancreatic cancer (PC) is marked by high mortality and resistance to conventional therapies, largely due to a dense desmoplastic stroma that promotes drug resistance and metastasis. This highlights the need for specific non-invasive diagnostic markers. MicroRNAs (miRNAs), known for regulating gene expression and influencing tumor behavior, have emerged as promising biomarkers. This study aimed to evaluate the expression of circulating miR-6875 and miR-1307 in PC patients to explore their diagnostic potential.<h4>Methods</h4>Blood, urine, and saliva samples were collected from 20 PC patients and 12 healthy controls. RNA extraction and cDNA synthesis were performed following standard protocols, and quantitative real-time PCR assays were used to quantify miR-6875 and miR-1307 expr"],"journal":["Discover oncology"],"pubmed_title":["Potential of circulating miR-6875 and miR-1307 as non-invasive diagnostic biomarkers for pancreatic cancer."],"pmcid":["PMC12474774"],"funding_grant_id":["S&T&RE/RP/147/E-2873/(22-23)/SANC/09/2022/907-915"],"pubmed_authors":["Arora A","Gupta R","Singh H","Bansal S","Lohani S","Aggarwal A","Sharma V","Semwal A","Sharma M"],"additional_accession":[]},"is_claimable":false,"name":"Potential of circulating miR-6875 and miR-1307 as non-invasive diagnostic biomarkers for pancreatic cancer.","description":"<h4>Aim</h4>Pancreatic cancer (PC) is marked by high mortality and resistance to conventional therapies, largely due to a dense desmoplastic stroma that promotes drug resistance and metastasis. This highlights the need for specific non-invasive diagnostic markers. MicroRNAs (miRNAs), known for regulating gene expression and influencing tumor behavior, have emerged as promising biomarkers. This study aimed to evaluate the expression of circulating miR-6875 and miR-1307 in PC patients to explore their diagnostic potential.<h4>Methods</h4>Blood, urine, and saliva samples were collected from 20 PC patients and 12 healthy controls. RNA extraction and cDNA synthesis were performed following standard protocols, and quantitative real-time PCR assays were used to quantify miR-6875 and miR-1307 expr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:43:32.915Z","creation":"2026-05-02T03:08:00.684Z"},"accession":"S-EPMC12474774","cross_references":{"pubmed":["41003822"],"doi":["10.1007/s12672-025-03490-3"]}}