biostudies-literatureSharma VDepartment of Science and Technology, Chandigarh Administration, India1710https://www.ebi.ac.uk/biostudies/studies/S-EPMC12474774biostudies-literatureUnknown16(1)<h4>Aim</h4>Pancreatic cancer (PC) is marked by high mortality and resistance to conventional therapies, largely due to a dense desmoplastic stroma that promotes drug resistance and metastasis. This highlights the need for specific non-invasive diagnostic markers. MicroRNAs (miRNAs), known for regulating gene expression and influencing tumor behavior, have emerged as promising biomarkers. This study aimed to evaluate the expression of circulating miR-6875 and miR-1307 in PC patients to explore their diagnostic potential.<h4>Methods</h4>Blood, urine, and saliva samples were collected from 20 PC patients and 12 healthy controls. RNA extraction and cDNA synthesis were performed following standard protocols, and quantitative real-time PCR assays were used to quantify miR-6875 and miR-1307 exprDiscover oncologyPotential of circulating miR-6875 and miR-1307 as non-invasive diagnostic biomarkers for pancreatic cancer.PMC12474774S&T&RE/RP/147/E-2873/(22-23)/SANC/09/2022/907-915Arora AGupta RSingh HBansal SLohani SAggarwal ASharma VSemwal ASharma MfalsePotential of circulating miR-6875 and miR-1307 as non-invasive diagnostic biomarkers for pancreatic cancer.<h4>Aim</h4>Pancreatic cancer (PC) is marked by high mortality and resistance to conventional therapies, largely due to a dense desmoplastic stroma that promotes drug resistance and metastasis. This highlights the need for specific non-invasive diagnostic markers. MicroRNAs (miRNAs), known for regulating gene expression and influencing tumor behavior, have emerged as promising biomarkers. This study aimed to evaluate the expression of circulating miR-6875 and miR-1307 in PC patients to explore their diagnostic potential.<h4>Methods</h4>Blood, urine, and saliva samples were collected from 20 PC patients and 12 healthy controls. RNA extraction and cDNA synthesis were performed following standard protocols, and quantitative real-time PCR assays were used to quantify miR-6875 and miR-1307 expr2025-01-01T00:00:00Z2025 Sep2026-06-03T21:43:32.915Z2026-05-02T03:08:00.684ZS-EPMC124747744100382210.1007/s12672-025-03490-3