{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Kendall C"],"pubmed_abstract":["Modern humans and archaic hominins, namely Denisovans and Neanderthals, have a long history of admixture. Some of these admixture events have allowed modern humans to adapt to new environments outside of Africa. Little research has been done on the impact of archaic introgression on genes associated with reproduction. In this study we report evidence of adaptive introgression of 118 genes within modern humans that have been previously associated with reproduction in mice or modern humans. We identified 11 archaic core haplotypes, three that have been positively selected, with 327 archaic alleles being genome-wide significant for a variety of traits. Over 300 of these variants were discovered to be eQTLs regulating 176 genes with 81% of the archaic eQTLs overlapping a core haplotype region "],"journal":["Communications biology"],"pagination":["1365"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12474892"],"repository":["biostudies-literature"],"pubmed_title":["Archaic adaptive introgression in modern human reproductive genes."],"pmcid":["PMC12474892"],"pubmed_authors":["Viola B","Parra EJ","Nooranikhojasteh A","Schillaci MA","Kendall C"],"additional_accession":[]},"is_claimable":false,"name":"Archaic adaptive introgression in modern human reproductive genes.","description":"Modern humans and archaic hominins, namely Denisovans and Neanderthals, have a long history of admixture. Some of these admixture events have allowed modern humans to adapt to new environments outside of Africa. Little research has been done on the impact of archaic introgression on genes associated with reproduction. In this study we report evidence of adaptive introgression of 118 genes within modern humans that have been previously associated with reproduction in mice or modern humans. We identified 11 archaic core haplotypes, three that have been positively selected, with 327 archaic alleles being genome-wide significant for a variety of traits. Over 300 of these variants were discovered to be eQTLs regulating 176 genes with 81% of the archaic eQTLs overlapping a core haplotype region ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T23:23:01.449Z","creation":"2026-05-03T03:11:29.478Z"},"accession":"S-EPMC12474892","cross_references":{"pubmed":["41006719"],"doi":["10.1038/s42003-025-08682-9"]}}