biostudies-literatureFrivold CU.S. Department of Health & Human Services | Centers for Disease Control and Prevention (CDC)8490https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475016biostudies-literatureUnknown16(1)Few population-based studies have evaluated the importance of pre-existing respiratory syncytial virus (RSV) antibody on RSV susceptibility among children and adults. We conducted a prospective, community-based cohort study among individuals aged 6 months-50 years in Oregon and Washington State, USA (June 2022-May 2023), with weekly symptom surveys and swab collection regardless of symptoms. Swabs were tested for RSV using RT-qPCR. Enrollment sera were tested for RSV prefusion F IgG binding (all participants) and neutralizing antibodies (pediatric participants). We detected 305 RSV illnesses among 3237 participants from 1188 households. Using proportional hazards regression, higher RSV binding antibody titers were associated with a lower estimated hazard of RSV among pediatric participantsNature communicationsCorrelates of risk of respiratory syncytial virus disease: a prospective cohort study.PMC1247501675D30121C12297Piliper EAFrivold CYetz NFeldstein LRStone JHatchie TLNaleway ALClark EMularski RAMohamed Bakhash SAKVarga AWolock CJLockwood CMHan PDBabu TMCarone MGreninger ALHoffman KLWeil AAGrindstaff SChu HYCox SNEnglund JAStarita LMarshall GReed JKuntz JLBoisvert CLLo NKfalseCorrelates of risk of respiratory syncytial virus disease: a prospective cohort study.Few population-based studies have evaluated the importance of pre-existing respiratory syncytial virus (RSV) antibody on RSV susceptibility among children and adults. We conducted a prospective, community-based cohort study among individuals aged 6 months-50 years in Oregon and Washington State, USA (June 2022-May 2023), with weekly symptom surveys and swab collection regardless of symptoms. Swabs were tested for RSV using RT-qPCR. Enrollment sera were tested for RSV prefusion F IgG binding (all participants) and neutralizing antibodies (pediatric participants). We detected 305 RSV illnesses among 3237 participants from 1188 households. Using proportional hazards regression, higher RSV binding antibody titers were associated with a lower estimated hazard of RSV among pediatric participants2025-01-01T00:00:00Z2025 Sep2026-06-03T21:35:49.366Z2026-05-02T03:07:34.391ZS-EPMC124750164100623310.1038/s41467-025-63434-x