{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lichawska-Cieslar A"],"funding":["Narodowe Centrum Nauki"],"pagination":["33222"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475053"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Skin homeostasis is ensured by a fine-tuned balance of proliferation and differentiation of keratinocytes, disturbances in which may initiate or promote skin diseases. The monocyte chemotactic protein-induced protein 3 (MCPIP3), or Regnase-3, is a ribonuclease belonging to the MCPIP family. Keratinocyte-specific loss of MCPIP3 results in increased expression of genes related to cell division, accelerated epidermal proliferation rate, and abnormal differentiation. The aim of this study was to gain insights into the mechanisms by which MCPIP3 affects keratinocyte biology. Immunoprecipitation-proteomics was applied to identify putative interactors of MCPIP3 in HaCaT keratinocytes. It revealed that MCPIP3 forms complexes with keratin 14, 14-3-3 proteins and modulators of cell polarity. Silenci"],"journal":["Scientific reports"],"pubmed_title":["MCPIP3/Regnase-3 binds 14-3-3 proteins and contributes to the regulation of the cell cycle in human immortalized keratinocytes."],"pmcid":["PMC12475053"],"funding_grant_id":["2022/47/D/NZ3/01654"],"pubmed_authors":["Eckhart L","Lichawska-Cieslar A","Szukala W","Jura J"],"additional_accession":[]},"is_claimable":false,"name":"MCPIP3/Regnase-3 binds 14-3-3 proteins and contributes to the regulation of the cell cycle in human immortalized keratinocytes.","description":"Skin homeostasis is ensured by a fine-tuned balance of proliferation and differentiation of keratinocytes, disturbances in which may initiate or promote skin diseases. The monocyte chemotactic protein-induced protein 3 (MCPIP3), or Regnase-3, is a ribonuclease belonging to the MCPIP family. Keratinocyte-specific loss of MCPIP3 results in increased expression of genes related to cell division, accelerated epidermal proliferation rate, and abnormal differentiation. The aim of this study was to gain insights into the mechanisms by which MCPIP3 affects keratinocyte biology. Immunoprecipitation-proteomics was applied to identify putative interactors of MCPIP3 in HaCaT keratinocytes. It revealed that MCPIP3 forms complexes with keratin 14, 14-3-3 proteins and modulators of cell polarity. Silenci","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T22:47:07.513Z","creation":"2026-05-02T03:11:29.453Z"},"accession":"S-EPMC12475053","cross_references":{"pubmed":["41006702"],"doi":["10.1038/s41598-025-18468-y"]}}