{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma L"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["8503"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475147"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Lower-frequency characteristics of the terahertz regime confer advantageous low photon energy for biochemical sensing while imposing inherent sensitivity constraints. Here, we demonstrate a terahertz asynchronous twin-comb sensor and an extra-spectrum sensing mechanism through cascading microchannel architecture within a metallic waveguide. The extra-spectrum sensing prefigures an enhanced sensitivity of 4 orders of magnitude compared to existing terahertz biosensing and surpasses its counterpart in the optical band. Hypersensitivities of 0.398 GHz mm<sup>2</sup> pg<sup>-1</sup> in trace detection manifest through the located characteristic resonance frequency beyond the spectrum domain. Additionally, we observed the photoisomerization of azo dye in the terahertz band with a photoresponse sensitivity of 0.91 GHz cm<sup>2</sup> mW<sup>-1</sup>, opening possibilities for photoactive material-assisted terahertz sensors. In summary, we instantiate an asynchronous twin-comb sensing beyond the spectrum domain, offering a perspective for ultrasensitive sensing, and promising applications in optical frequency comb precision metrology, artificial intelligence photonics, and integrated sensing and communications."],"journal":["Nature communications"],"pubmed_title":["Terahertz asynchronous twin-comb for prefiguring hypersensitivity beyond spectrum domain."],"pmcid":["PMC12475147"],"funding_grant_id":["62205160","62371258","624B2075","62335012","62435010"],"pubmed_authors":["Fan F","Ma L","Feng J","Shen P","Song C","Ji Y","Wang X","Chang S"],"additional_accession":[]},"is_claimable":false,"name":"Terahertz asynchronous twin-comb for prefiguring hypersensitivity beyond spectrum domain.","description":"Lower-frequency characteristics of the terahertz regime confer advantageous low photon energy for biochemical sensing while imposing inherent sensitivity constraints. Here, we demonstrate a terahertz asynchronous twin-comb sensor and an extra-spectrum sensing mechanism through cascading microchannel architecture within a metallic waveguide. The extra-spectrum sensing prefigures an enhanced sensitivity of 4 orders of magnitude compared to existing terahertz biosensing and surpasses its counterpart in the optical band. Hypersensitivities of 0.398 GHz mm<sup>2</sup> pg<sup>-1</sup> in trace detection manifest through the located characteristic resonance frequency beyond the spectrum domain. Additionally, we observed the photoisomerization of azo dye in the terahertz band with a photoresponse sensitivity of 0.91 GHz cm<sup>2</sup> mW<sup>-1</sup>, opening possibilities for photoactive material-assisted terahertz sensors. In summary, we instantiate an asynchronous twin-comb sensing beyond the spectrum domain, offering a perspective for ultrasensitive sensing, and promising applications in optical frequency comb precision metrology, artificial intelligence photonics, and integrated sensing and communications.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:34:57.867Z","creation":"2026-05-02T03:07:56.821Z"},"accession":"S-EPMC12475147","cross_references":{"pubmed":["41006296"],"doi":["10.1038/s41467-025-63513-z"]}}