{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Jiang NF"],"pubmed_abstract":["This study aimed to evaluate the clinical significance and underlying biological mechanisms of LIM kinase 1 (LIMK1) in hepatocellular carcinoma (HCC). Using multi-omics data from TCGA and ICGC cohorts, we analyzed LIMK1 expression and its prognostic value. Clinical validation was performed via immunohistochemistry on tissue microarray specimens. A multivariate Cox model integrating LIMK1 and clinicopathological features was constructed and evaluated using machine learning. Tumor immune microenvironment was profiled using multiple immune deconvolution algorithms. Immunotherapy cohorts and drug sensitivity data were leveraged to assess therapeutic implications. LIMK1 was significantly overexpressed in HCC tissues across all cohorts and correlated with poor overall survival (TCGA HR = 2.26, P"],"journal":["Scientific reports"],"pagination":["33191"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475169"],"repository":["biostudies-literature"],"pubmed_title":["LIMK1 is a prognosis and treatment biomarker in hepatocellular carcinoma."],"pmcid":["PMC12475169"],"pubmed_authors":["Jiang NF","Zhang HP","Zhou Z"],"additional_accession":[]},"is_claimable":false,"name":"LIMK1 is a prognosis and treatment biomarker in hepatocellular carcinoma.","description":"This study aimed to evaluate the clinical significance and underlying biological mechanisms of LIM kinase 1 (LIMK1) in hepatocellular carcinoma (HCC). Using multi-omics data from TCGA and ICGC cohorts, we analyzed LIMK1 expression and its prognostic value. Clinical validation was performed via immunohistochemistry on tissue microarray specimens. A multivariate Cox model integrating LIMK1 and clinicopathological features was constructed and evaluated using machine learning. Tumor immune microenvironment was profiled using multiple immune deconvolution algorithms. Immunotherapy cohorts and drug sensitivity data were leveraged to assess therapeutic implications. LIMK1 was significantly overexpressed in HCC tissues across all cohorts and correlated with poor overall survival (TCGA HR = 2.26, P","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-01T03:20:47.058Z","creation":"2026-05-01T03:11:22.617Z"},"accession":"S-EPMC12475169","cross_references":{"pubmed":["41006440"],"doi":["10.1038/s41598-025-17732-5"]}}