{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mantuano P"],"funding":["Charlies Fund","Duchenne UK","TUBITAK"],"pagination":["33210"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475182"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Accessibility to outcome measures that reliably assess disease pathology in preclinical studies are vital, especially for rare disorders such as Duchenne muscular dystrophy (DMD). The non-invasive technique of electrical impedance myography (EIM) has shown potential as an outcome measure in patients and mouse models of neuromuscular disorders. However, these preclinical observations have been limited to a single site. Here, we performed a longitudinal, parallel two-site study to assess the potential of EIM as an outcome measure by using two DMD mouse models - mdx mice on a C57BL/10ScSn/J or DBA/2J genetic background - differing in disease severity, and being hypertrophic and atrophic, respectively, over a ten-month period, in which mice were evaluated monthly. We found that longitudinally "],"journal":["Scientific reports"],"pubmed_title":["A two-site collaborative study of electrical impedance myography for evaluation of disease progression in murine Duchenne muscular dystrophy models."],"pmcid":["PMC12475182"],"funding_grant_id":["na","2219-International Postdoctoral Research Fellowship Program for Turkish Citizens"],"pubmed_authors":["Boccanegra B","Rutkove S","Cappellari O","Putker K","Engelbeen S","Pandeya S","Cobb BS","van Putten M","Van De Vijver D","Tulimiero L","Schneider AF","Mantuano P","Tanganyika-de Winter C","Nagy JA"],"additional_accession":[]},"is_claimable":false,"name":"A two-site collaborative study of electrical impedance myography for evaluation of disease progression in murine Duchenne muscular dystrophy models.","description":"Accessibility to outcome measures that reliably assess disease pathology in preclinical studies are vital, especially for rare disorders such as Duchenne muscular dystrophy (DMD). The non-invasive technique of electrical impedance myography (EIM) has shown potential as an outcome measure in patients and mouse models of neuromuscular disorders. However, these preclinical observations have been limited to a single site. Here, we performed a longitudinal, parallel two-site study to assess the potential of EIM as an outcome measure by using two DMD mouse models - mdx mice on a C57BL/10ScSn/J or DBA/2J genetic background - differing in disease severity, and being hypertrophic and atrophic, respectively, over a ten-month period, in which mice were evaluated monthly. We found that longitudinally ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:33:53.21Z","creation":"2026-05-01T03:11:21.548Z"},"accession":"S-EPMC12475182","cross_references":{"pubmed":["41006509"],"doi":["10.1038/s41598-025-17137-4"]}}