{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Subramanian A"],"funding":["U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)","NCI NIH HHS"],"pagination":["8473"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475200"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and few studies have comprehensively investigated the immune microenvironment and rare lymphocyte-predominant (LP) cells. Here we develop a NLPHL specific lymphocyte-predominant ecotype (LPE) model to identify 34 distinct cell states across 14 cell types that co-occur within 3 LPEs for 171 cases. LPE1 and LPE2 were characterized by immunosuppressive microenvironments with high expression of B2M on LP cells, CD8 T-cell exhaustion, immune checkpoint genes expressed by follicular T-cells, and an improved freedom from progression compared to LPE3 in training (n = 109, with 65% LPE1/2) and validation cohorts (n = 62, with 61% LPE1/2). We validate the co-occurrence and co-localization of cell states using spatial transcrip"],"journal":["Nature communications"],"pubmed_title":["Distinct cell state ecosystems for nodular lymphocyte-predominant Hodgkin lymphoma."],"pmcid":["PMC12475200"],"funding_grant_id":["K08 CA266824","K08CA266824"],"pubmed_authors":["Binkley MS","Sykorova A","Diehn M","Kumar P","Subramanian A","Newman AM","Vega F","Ramsay A","Su S","Alig S","Paulino D","Prochazka V","Zhao S","Moding EJ","Hoppe RT","Marks LJ","Park NJ","Palese M","Milito C","Noordenbos T","Pinnix C","Kalbasi A","Zhu C","Steiner R","Mocikova H","Alizadeh AA","Younes S","Flerlage J","Advani RH","Schroers-Martin J","Flerlage T","Allen P","West R","Natkunam Y"],"additional_accession":[]},"is_claimable":false,"name":"Distinct cell state ecosystems for nodular lymphocyte-predominant Hodgkin lymphoma.","description":"Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and few studies have comprehensively investigated the immune microenvironment and rare lymphocyte-predominant (LP) cells. Here we develop a NLPHL specific lymphocyte-predominant ecotype (LPE) model to identify 34 distinct cell states across 14 cell types that co-occur within 3 LPEs for 171 cases. LPE1 and LPE2 were characterized by immunosuppressive microenvironments with high expression of B2M on LP cells, CD8 T-cell exhaustion, immune checkpoint genes expressed by follicular T-cells, and an improved freedom from progression compared to LPE3 in training (n = 109, with 65% LPE1/2) and validation cohorts (n = 62, with 61% LPE1/2). We validate the co-occurrence and co-localization of cell states using spatial transcrip","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:34:22.766Z","creation":"2026-05-01T03:11:31.701Z"},"accession":"S-EPMC12475200","cross_references":{"pubmed":["41006203"],"doi":["10.1038/s41467-025-63339-9"]}}