{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu X"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["8474"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475412"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["The chirality-induced spin selectivity (CISS) effect is a state-of-art strategy for chiral detectability enhancement. For the first time, high-performance gas-phase chiral detectors based on the CISS effect were prepared using organic polymer, to address the challenges in accurately and portably detecting gas-phase chiral enantiomers in analytical chemistry. Here, a series of block copolymers poly(3-hexylthiophene)-block poly(phenyl isocyanate) (P3HT-PPI) were synthesized, combining a chiral helical structure and significantly improved electrical conductivity to regulate CISS effect by PPI ratio for precise, portable chiral recognition. P3HT<sub>80</sub>-PPI<sub>30</sub> demonstrates exceptional spin polarization up to 70.8%. The gas enantiomer detector based on P3HT<sub>80</sub>-PPI<sub>30</sub> exhibits excellent chiral distinguish capability of limonene enantiomers with current asymmetry factor up to 0.50, real-time detection, high reversibility, and linear concertation-dependence of response. An 'electronic dichroism' system based on the circuit combining chiral and achiral sensing elements, was developed for real-time visualization of limonene enantiomeric excess. Designing materials with CISS effect incorporating spin-polarized electrons in chiral enantiomer recognition and combing with conductive properties for converting chemical signals to electrical outputs, provides an effective strategy for the next-generation real-time, efficient detection of multiple chiral enantiomers."],"journal":["Nature communications"],"pubmed_title":["High-performance gas-phase chiral enantiomer detectors based on chiral-induced spin selectivity effect."],"pmcid":["PMC12475412"],"funding_grant_id":["62274053","52273172"],"pubmed_authors":["Liu J","Jiang L","Ni F","Wei S","Wang X","Wu X","Qiu L"],"additional_accession":[]},"is_claimable":false,"name":"High-performance gas-phase chiral enantiomer detectors based on chiral-induced spin selectivity effect.","description":"The chirality-induced spin selectivity (CISS) effect is a state-of-art strategy for chiral detectability enhancement. For the first time, high-performance gas-phase chiral detectors based on the CISS effect were prepared using organic polymer, to address the challenges in accurately and portably detecting gas-phase chiral enantiomers in analytical chemistry. Here, a series of block copolymers poly(3-hexylthiophene)-block poly(phenyl isocyanate) (P3HT-PPI) were synthesized, combining a chiral helical structure and significantly improved electrical conductivity to regulate CISS effect by PPI ratio for precise, portable chiral recognition. P3HT<sub>80</sub>-PPI<sub>30</sub> demonstrates exceptional spin polarization up to 70.8%. The gas enantiomer detector based on P3HT<sub>80</sub>-PPI<sub>30</sub> exhibits excellent chiral distinguish capability of limonene enantiomers with current asymmetry factor up to 0.50, real-time detection, high reversibility, and linear concertation-dependence of response. An 'electronic dichroism' system based on the circuit combining chiral and achiral sensing elements, was developed for real-time visualization of limonene enantiomeric excess. Designing materials with CISS effect incorporating spin-polarized electrons in chiral enantiomer recognition and combing with conductive properties for converting chemical signals to electrical outputs, provides an effective strategy for the next-generation real-time, efficient detection of multiple chiral enantiomers.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T22:48:42.095Z","creation":"2026-05-02T03:11:50.133Z"},"accession":"S-EPMC12475412","cross_references":{"pubmed":["41006253"],"doi":["10.1038/s41467-025-63347-9"]}}