biostudies-literatureWu XNational Natural Science Foundation of China (National Science Foundation of China)8474https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475412biostudies-literatureUnknown16(1)The chirality-induced spin selectivity (CISS) effect is a state-of-art strategy for chiral detectability enhancement. For the first time, high-performance gas-phase chiral detectors based on the CISS effect were prepared using organic polymer, to address the challenges in accurately and portably detecting gas-phase chiral enantiomers in analytical chemistry. Here, a series of block copolymers poly(3-hexylthiophene)-block poly(phenyl isocyanate) (P3HT-PPI) were synthesized, combining a chiral helical structure and significantly improved electrical conductivity to regulate CISS effect by PPI ratio for precise, portable chiral recognition. P3HT₈₀-PPI₃₀ demonstrates exceptional spin polarization up to 70.8%. The gas enantiomer detector based on P3HT₈₀-PPI₃₀ exhibits excellent chiral distinguish capability of limonene enantiomers with current asymmetry factor up to 0.50, real-time detection, high reversibility, and linear concertation-dependence of response. An 'electronic dichroism' system based on the circuit combining chiral and achiral sensing elements, was developed for real-time visualization of limonene enantiomeric excess. Designing materials with CISS effect incorporating spin-polarized electrons in chiral enantiomer recognition and combing with conductive properties for converting chemical signals to electrical outputs, provides an effective strategy for the next-generation real-time, efficient detection of multiple chiral enantiomers.Nature communicationsHigh-performance gas-phase chiral enantiomer detectors based on chiral-induced spin selectivity effect.PMC124754126227405352273172Liu JJiang LNi FWei SWang XWu XQiu LfalseHigh-performance gas-phase chiral enantiomer detectors based on chiral-induced spin selectivity effect.The chirality-induced spin selectivity (CISS) effect is a state-of-art strategy for chiral detectability enhancement. For the first time, high-performance gas-phase chiral detectors based on the CISS effect were prepared using organic polymer, to address the challenges in accurately and portably detecting gas-phase chiral enantiomers in analytical chemistry. Here, a series of block copolymers poly(3-hexylthiophene)-block poly(phenyl isocyanate) (P3HT-PPI) were synthesized, combining a chiral helical structure and significantly improved electrical conductivity to regulate CISS effect by PPI ratio for precise, portable chiral recognition. P3HT₈₀-PPI₃₀ demonstrates exceptional spin polarization up to 70.8%. The gas enantiomer detector based on P3HT₈₀-PPI₃₀ exhibits excellent chiral distinguish capability of limonene enantiomers with current asymmetry factor up to 0.50, real-time detection, high reversibility, and linear concertation-dependence of response. An 'electronic dichroism' system based on the circuit combining chiral and achiral sensing elements, was developed for real-time visualization of limonene enantiomeric excess. Designing materials with CISS effect incorporating spin-polarized electrons in chiral enantiomer recognition and combing with conductive properties for converting chemical signals to electrical outputs, provides an effective strategy for the next-generation real-time, efficient detection of multiple chiral enantiomers.2025-01-01T00:00:00Z2025 Sep2026-06-03T22:48:42.095Z2026-05-02T03:11:50.133ZS-EPMC124754124100625310.1038/s41467-025-63347-9