biostudies-literaturePark KIKorea Health Industry Development Institute33177https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475458biostudies-literatureUnknown15(1)Despite the increasing number of available antiseizure medications (ASMs), optimal medical therapy is still a process of trial and error. We aimed to predict the responsiveness of various ASMs based on initial tests using artificial intelligence. The study consisted of 2586 patients fulfilling the following criteria: (1) first visit to the epileptologists from 2008 to 2017, (2) a diagnosis of epilepsy, and 3) ≥ three years of follow-up duration. The clinical characteristics, ASM history, seizure frequency, laboratory, EEG, and MRI results, were collected. Machine algorithms were utilized to predict the responsiveness of specific regimens. Valproate showed the highest area under curve (AUC), 0.636. The AUCs of levetiracetam, oxcarbazepine, and lamotrigine were 0.614, 0.633, and 0.674. The AScientific reportsPrediction of personalized antiseizure medications response based on clinical signatures in epilepsy.PMC12475458RS-2023-00265638Lee SKPark KIHwang SJung KHKim YGLee SBKim YJChu KLee STJung KYShin YMoon JSon HfalsePrediction of personalized antiseizure medications response based on clinical signatures in epilepsy.Despite the increasing number of available antiseizure medications (ASMs), optimal medical therapy is still a process of trial and error. We aimed to predict the responsiveness of various ASMs based on initial tests using artificial intelligence. The study consisted of 2586 patients fulfilling the following criteria: (1) first visit to the epileptologists from 2008 to 2017, (2) a diagnosis of epilepsy, and 3) ≥ three years of follow-up duration. The clinical characteristics, ASM history, seizure frequency, laboratory, EEG, and MRI results, were collected. Machine algorithms were utilized to predict the responsiveness of specific regimens. Valproate showed the highest area under curve (AUC), 0.636. The AUCs of levetiracetam, oxcarbazepine, and lamotrigine were 0.614, 0.633, and 0.674. The A2025-01-01T00:00:00Z2025 Sep2026-07-15T01:48:10.987Z2026-06-27T03:17:42.668ZS-EPMC124754584100650710.1038/s41598-025-16881-x