biostudies-literatureUnknown135(10)Bowen AJ<h4>Objective</h4>There is currently not a marker of disease severity in idiopathic subglottic stenosis (iSGS). Our objective was to characterize iSGS patients' disease severity using endoscopic surgery rates.<h4>Methods</h4>This was a two-center retrospective analysis of iSGS patients with a minimum of 4 years of follow up following an initial endoscopic procedure (laser wedge excision (LWE) or endoscopic dilation (ED)). Disease severity was classified into Groups A-C, based on whether patients had fewer (Group A), the same number (Group B), or more surgeries (Group C) in years 3-5 compared to years 1 and 2. Disease severity proportions were compared across institutions using chi-square analysis. Nonparametric testing compared clinical characteristics such as age, BMI, and GERD across sevThe Laryngoscope3766-3773https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475557biostudies-literatureCharacterizing Disease Severity Through Surgical Recurrence Rates in Idiopathic Subglottic Stenosis.PMC12475557Ali HBayan SEkbom DKoster MBowen AJRing SDavis RKhalil YFrancis DOAwadallah AMcCalla MRoitman ALeverson GXie KDailey SHEdell EfalseCharacterizing Disease Severity Through Surgical Recurrence Rates in Idiopathic Subglottic Stenosis.<h4>Objective</h4>There is currently not a marker of disease severity in idiopathic subglottic stenosis (iSGS). Our objective was to characterize iSGS patients' disease severity using endoscopic surgery rates.<h4>Methods</h4>This was a two-center retrospective analysis of iSGS patients with a minimum of 4 years of follow up following an initial endoscopic procedure (laser wedge excision (LWE) or endoscopic dilation (ED)). Disease severity was classified into Groups A-C, based on whether patients had fewer (Group A), the same number (Group B), or more surgeries (Group C) in years 3-5 compared to years 1 and 2. Disease severity proportions were compared across institutions using chi-square analysis. Nonparametric testing compared clinical characteristics such as age, BMI, and GERD across sev2025-01-01T00:00:00Z2025 Oct2026-06-03T23:09:20.541Z2026-05-02T03:11:59.651ZS-EPMC124755574039658410.1002/lary.32280