{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27"],"submitter":["Hallab A"],"pubmed_abstract":["<h4>Introduction</h4>Chronic emotional stress is a well-recognized risk factor for psychiatric and cardiometabolic disorders. The mediating role of low-grade inflammation in older, ethnically diverse populations has never been studied.<h4>Methods</h4>The multiethnic ≥50-year-old study population is a subset of the Health and Aging Brain Study: Health Disparities (HABS-HD) study. Adjusted logistic and linear regression were used to assess associations. Statistical mediation analysis with non-parametric bootstrapping of confidence intervals was used to determine the intermediate role of Interleukin-6 (IL-6).<h4>Results</h4>The study included 2173 participants (50-92 years). Black participants disclosed higher chronic stress levels than White and Hispanic participants. Having a chronic stress"],"journal":["International journal of cardiology. Cardiovascular risk and prevention"],"pagination":["200510"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475582"],"repository":["biostudies-literature"],"pubmed_title":["Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population."],"pmcid":["PMC12475582"],"pubmed_authors":["Petersen M","Vardarajan B","Zhang F","Hall JR","Lee J","Cheema A","Barber R","Ances B","Vig R","Mason D","Mielke M","Shi Y","McColl R","Babulal G","Hill C","King K","Borzage M","Mindt MR","Okonkwo O","Large S","Llibre-Guerra J","HABS-HD Investigators","Hallab A","Mapstone M","Christian B","HABS-HD MPIs","Kind A","Palmer R","Barnes L","Rissman R","Braskie M","Nandy R","Phillips N","Donohue M","Zhou Z","Raman R","Johnsonthe L","Cohen A","O'Bryant SE","Yaffe K","Toga A","Vintimilla R","Health and Aging Brain Study (HABS-HD) Study Team"],"additional_accession":[]},"is_claimable":false,"name":"Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population.","description":"<h4>Introduction</h4>Chronic emotional stress is a well-recognized risk factor for psychiatric and cardiometabolic disorders. The mediating role of low-grade inflammation in older, ethnically diverse populations has never been studied.<h4>Methods</h4>The multiethnic ≥50-year-old study population is a subset of the Health and Aging Brain Study: Health Disparities (HABS-HD) study. Adjusted logistic and linear regression were used to assess associations. Statistical mediation analysis with non-parametric bootstrapping of confidence intervals was used to determine the intermediate role of Interleukin-6 (IL-6).<h4>Results</h4>The study included 2173 participants (50-92 years). Black participants disclosed higher chronic stress levels than White and Hispanic participants. Having a chronic stress","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-04T05:05:46.773Z","creation":"2026-06-03T03:07:46.589Z"},"accession":"S-EPMC12475582","cross_references":{"pubmed":["41019535"],"doi":["10.1016/j.ijcrp.2025.200510"]}}