biostudies-literatureUnknown27Hallab A<h4>Introduction</h4>Chronic emotional stress is a well-recognized risk factor for psychiatric and cardiometabolic disorders. The mediating role of low-grade inflammation in older, ethnically diverse populations has never been studied.<h4>Methods</h4>The multiethnic ≥50-year-old study population is a subset of the Health and Aging Brain Study: Health Disparities (HABS-HD) study. Adjusted logistic and linear regression were used to assess associations. Statistical mediation analysis with non-parametric bootstrapping of confidence intervals was used to determine the intermediate role of Interleukin-6 (IL-6).<h4>Results</h4>The study included 2173 participants (50-92 years). Black participants disclosed higher chronic stress levels than White and Hispanic participants. Having a chronic stressInternational journal of cardiology. Cardiovascular risk and prevention200510https://www.ebi.ac.uk/biostudies/studies/S-EPMC12475582biostudies-literatureChronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population.PMC12475582Petersen MVardarajan BZhang FHall JRLee JCheema ABarber RAnces BVig RMason DMielke MShi YMcColl RBabulal GHill CKing KBorzage MMindt MROkonkwo OLarge SLlibre-Guerra JHABS-HD InvestigatorsHallab AMapstone MChristian BHABS-HD MPIsKind APalmer RBarnes LRissman RBraskie MNandy RPhillips NDonohue MZhou ZRaman RJohnsonthe LCohen AO'Bryant SEYaffe KToga AVintimilla RHealth and Aging Brain Study (HABS-HD) Study TeamfalseChronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population.<h4>Introduction</h4>Chronic emotional stress is a well-recognized risk factor for psychiatric and cardiometabolic disorders. The mediating role of low-grade inflammation in older, ethnically diverse populations has never been studied.<h4>Methods</h4>The multiethnic ≥50-year-old study population is a subset of the Health and Aging Brain Study: Health Disparities (HABS-HD) study. Adjusted logistic and linear regression were used to assess associations. Statistical mediation analysis with non-parametric bootstrapping of confidence intervals was used to determine the intermediate role of Interleukin-6 (IL-6).<h4>Results</h4>The study included 2173 participants (50-92 years). Black participants disclosed higher chronic stress levels than White and Hispanic participants. Having a chronic stress2025-01-01T00:00:00Z2025 Dec2026-06-04T05:05:46.773Z2026-06-03T03:07:46.589ZS-EPMC124755824101953510.1016/j.ijcrp.2025.200510