{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kosho MXF"],"funding":["ORANGEForce project within the ORANGEHealth consortium funded by Health-Holland.nl, div. Life Sciences & Health with grant number LSHM21064","Philips Oral Healthcare","TKI HealthHolland","Dutch Society of Periodontology (NVvP)","Sunstar Suisse S.A","material support by Labonovum BV"],"pagination":["762-774"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12476085"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["60(8)"],"pubmed_abstract":["<h4>Aims</h4>To explore the potential of metabolomic profiles of oral rinse samples to distinguish between patients with severe periodontitis (stage III/IV) and non-periodontitis controls. This is coupled to an analysis of differences in metabolomic profiles between individuals without periodontitis, patients with localized periodontitis, and patients with generalized periodontitis.<h4>Methods</h4>Periodontitis patients and controls were recruited, all aged ≥ 40 years. Study participants were asked to rinse vigorously for 30 s with 10 mL phosphate buffered saline. Metabolites were identified using a semi-targeted liquid chromatography tandem mass spectrometry (LC-MS/MS) platform.<h4>Results</h4>In total, 38 periodontitis patients (18 localized, 20 generalized stage III/IV periodontitis pat"],"journal":["Journal of periodontal research"],"pubmed_title":["Metabolomic Profiles of Oral Rinse Samples to Distinguish Severe Periodontitis Patients From Non-Periodontitis Controls."],"pmcid":["PMC12476085"],"funding_grant_id":["LSHM17003"],"pubmed_authors":["Neefjes J","Giera M","Loos BG","Ciurli A","Kosho MXF"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomic Profiles of Oral Rinse Samples to Distinguish Severe Periodontitis Patients From Non-Periodontitis Controls.","description":"<h4>Aims</h4>To explore the potential of metabolomic profiles of oral rinse samples to distinguish between patients with severe periodontitis (stage III/IV) and non-periodontitis controls. This is coupled to an analysis of differences in metabolomic profiles between individuals without periodontitis, patients with localized periodontitis, and patients with generalized periodontitis.<h4>Methods</h4>Periodontitis patients and controls were recruited, all aged ≥ 40 years. Study participants were asked to rinse vigorously for 30 s with 10 mL phosphate buffered saline. Metabolites were identified using a semi-targeted liquid chromatography tandem mass spectrometry (LC-MS/MS) platform.<h4>Results</h4>In total, 38 periodontitis patients (18 localized, 20 generalized stage III/IV periodontitis pat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-04T01:37:44.924Z","creation":"2026-05-04T03:12:04.266Z"},"accession":"S-EPMC12476085","cross_references":{"pubmed":["40083241"],"doi":["10.1111/jre.13379"]}}