{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2025"],"submitter":["Diaz de Sandy-Galan DA"],"pubmed_abstract":["Although obesity is the most common risk factor for hepatic steatosis, this disease may occur in normal-weight individuals. While gut microbial metabolites such as short-chain fatty acids (SCFAs) have been associated with obesity and metabolic disease, the relationship among fecal SCFA concentrations, SCFA-producing bacteria, and hepatic steatosis with and without obesity is not fully understood. This pilot study aimed to compare fecal SCFA concentrations and SCFA-producing gut bacteria in four study groups: 7 individuals with normal-weight and normal alanine aminotransferase levels (Nw-N ALT), 7 individuals with normal-weight and elevated ALT levels (Nw-E ALT), 12 individuals with obesity and normal ALT levels and (Ob-N ALT), and 18 individuals with obesity and elevated ALT levels (Ob-E A"],"journal":["Journal of nutrition and metabolism"],"pagination":["6652392"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12476282"],"repository":["biostudies-literature"],"pubmed_title":["Association of Gut Microbiota-Derived Short-Chain Fatty Acids With Persistent Elevated Serum Transaminase Levels in Normal Weight and Obesity: A Pilot Study."],"pmcid":["PMC12476282"],"pubmed_authors":["Diaz de Sandy-Galan DA","Dominguez-Calderon I","Cerqueda-Garcia D","Villarreal-Molina T","Velazquez-Cruz R","Leon-Mimila P","Maldonado-Hernandez J","Rodriguez-Cruz M","Olivares-Arevalo M","Canizales-Quinteros S","Salmeron J","Lopez-Contreras B","Villamil-Ramirez H"],"additional_accession":[]},"is_claimable":false,"name":"Association of Gut Microbiota-Derived Short-Chain Fatty Acids With Persistent Elevated Serum Transaminase Levels in Normal Weight and Obesity: A Pilot Study.","description":"Although obesity is the most common risk factor for hepatic steatosis, this disease may occur in normal-weight individuals. While gut microbial metabolites such as short-chain fatty acids (SCFAs) have been associated with obesity and metabolic disease, the relationship among fecal SCFA concentrations, SCFA-producing bacteria, and hepatic steatosis with and without obesity is not fully understood. This pilot study aimed to compare fecal SCFA concentrations and SCFA-producing gut bacteria in four study groups: 7 individuals with normal-weight and normal alanine aminotransferase levels (Nw-N ALT), 7 individuals with normal-weight and elevated ALT levels (Nw-E ALT), 12 individuals with obesity and normal ALT levels and (Ob-N ALT), and 18 individuals with obesity and elevated ALT levels (Ob-E A","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T23:53:34.781Z","creation":"2026-05-03T03:11:38.93Z"},"accession":"S-EPMC12476282","cross_references":{"pubmed":["41019148"],"doi":["10.1155/jnme/6652392"]}}