biostudies-literatureUnknown2025Diaz de Sandy-Galan DAAlthough obesity is the most common risk factor for hepatic steatosis, this disease may occur in normal-weight individuals. While gut microbial metabolites such as short-chain fatty acids (SCFAs) have been associated with obesity and metabolic disease, the relationship among fecal SCFA concentrations, SCFA-producing bacteria, and hepatic steatosis with and without obesity is not fully understood. This pilot study aimed to compare fecal SCFA concentrations and SCFA-producing gut bacteria in four study groups: 7 individuals with normal-weight and normal alanine aminotransferase levels (Nw-N ALT), 7 individuals with normal-weight and elevated ALT levels (Nw-E ALT), 12 individuals with obesity and normal ALT levels and (Ob-N ALT), and 18 individuals with obesity and elevated ALT levels (Ob-E AJournal of nutrition and metabolism6652392https://www.ebi.ac.uk/biostudies/studies/S-EPMC12476282biostudies-literatureAssociation of Gut Microbiota-Derived Short-Chain Fatty Acids With Persistent Elevated Serum Transaminase Levels in Normal Weight and Obesity: A Pilot Study.PMC12476282Diaz de Sandy-Galan DADominguez-Calderon ICerqueda-Garcia DVillarreal-Molina TVelazquez-Cruz RLeon-Mimila PMaldonado-Hernandez JRodriguez-Cruz MOlivares-Arevalo MCanizales-Quinteros SSalmeron JLopez-Contreras BVillamil-Ramirez HfalseAssociation of Gut Microbiota-Derived Short-Chain Fatty Acids With Persistent Elevated Serum Transaminase Levels in Normal Weight and Obesity: A Pilot Study.Although obesity is the most common risk factor for hepatic steatosis, this disease may occur in normal-weight individuals. While gut microbial metabolites such as short-chain fatty acids (SCFAs) have been associated with obesity and metabolic disease, the relationship among fecal SCFA concentrations, SCFA-producing bacteria, and hepatic steatosis with and without obesity is not fully understood. This pilot study aimed to compare fecal SCFA concentrations and SCFA-producing gut bacteria in four study groups: 7 individuals with normal-weight and normal alanine aminotransferase levels (Nw-N ALT), 7 individuals with normal-weight and elevated ALT levels (Nw-E ALT), 12 individuals with obesity and normal ALT levels and (Ob-N ALT), and 18 individuals with obesity and elevated ALT levels (Ob-E A2025-01-01T00:00:00Z20252026-06-03T23:53:34.781Z2026-05-03T03:11:38.93ZS-EPMC124762824101914810.1155/jnme/6652392