{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Oliverio A"],"pubmed_abstract":["<h4>Background</h4>Women carriers of <i>BRCA1/2</i> mutations face a very high lifetime risk (penetrance) of developing breast and/or ovarian cancer. A sizeable proportion of carriers, however, does not develop cancer at all or develop it only late in life, thus suggesting a potential modulation of this risk. Epidemiological studies have suggested that other genetic (polymorphisms) and environmental factors (lifestyle) affect penetrance. However, data regarding these associations mainly come from retrospective case-control analyses and the results are likely to be distorted by bias.<h4>Aims</h4>The e-BRAVE (Brca, ReseArch, Virtual, Education) study aims to create a web-based prospective cohort and biological bank of unaffected women carriers of <i>BRCA1/2</i> mutations to investigate the r"],"journal":["Tumori"],"pagination":["3008916251353420"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12476487"],"repository":["biostudies-literature"],"pubmed_title":["The e-BRAVE study: A prospective web-based cohort and biobank of women carriers of BRCA mutations."],"pmcid":["PMC12476487"],"pubmed_authors":["Patruno M","Magno S","Bruno E","Tommasi S","Morelli D","Cesareo A","Fruscio R","Bianchi M","Oliverio A","Schiavone S","Galasso L","Franceschini G","Ferrari A","Manoukian S","Sassi G","Pasanisi P","Di Gennaro M","Daniele A","Venturelli E","Chiodoni C","Pighini C","Meli C"],"additional_accession":[]},"is_claimable":false,"name":"The e-BRAVE study: A prospective web-based cohort and biobank of women carriers of BRCA mutations.","description":"<h4>Background</h4>Women carriers of <i>BRCA1/2</i> mutations face a very high lifetime risk (penetrance) of developing breast and/or ovarian cancer. A sizeable proportion of carriers, however, does not develop cancer at all or develop it only late in life, thus suggesting a potential modulation of this risk. Epidemiological studies have suggested that other genetic (polymorphisms) and environmental factors (lifestyle) affect penetrance. However, data regarding these associations mainly come from retrospective case-control analyses and the results are likely to be distorted by bias.<h4>Aims</h4>The e-BRAVE (Brca, ReseArch, Virtual, Education) study aims to create a web-based prospective cohort and biological bank of unaffected women carriers of <i>BRCA1/2</i> mutations to investigate the r","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-03T22:57:37.562Z","creation":"2026-05-02T03:12:16.8Z"},"accession":"S-EPMC12476487","cross_references":{"pubmed":["40782011"],"doi":["10.1177/03008916251353420"]}}