biostudies-literatureUnknownOliverio A<h4>Background</h4>Women carriers of <i>BRCA1/2</i> mutations face a very high lifetime risk (penetrance) of developing breast and/or ovarian cancer. A sizeable proportion of carriers, however, does not develop cancer at all or develop it only late in life, thus suggesting a potential modulation of this risk. Epidemiological studies have suggested that other genetic (polymorphisms) and environmental factors (lifestyle) affect penetrance. However, data regarding these associations mainly come from retrospective case-control analyses and the results are likely to be distorted by bias.<h4>Aims</h4>The e-BRAVE (Brca, ReseArch, Virtual, Education) study aims to create a web-based prospective cohort and biological bank of unaffected women carriers of <i>BRCA1/2</i> mutations to investigate the rTumori3008916251353420https://www.ebi.ac.uk/biostudies/studies/S-EPMC12476487biostudies-literatureThe e-BRAVE study: A prospective web-based cohort and biobank of women carriers of BRCA mutations.PMC12476487Patruno MMagno SBruno ETommasi SMorelli DCesareo AFruscio RBianchi MOliverio ASchiavone SGalasso LFranceschini GFerrari AManoukian SSassi GPasanisi PDi Gennaro MDaniele AVenturelli EChiodoni CPighini CMeli CfalseThe e-BRAVE study: A prospective web-based cohort and biobank of women carriers of BRCA mutations.<h4>Background</h4>Women carriers of <i>BRCA1/2</i> mutations face a very high lifetime risk (penetrance) of developing breast and/or ovarian cancer. A sizeable proportion of carriers, however, does not develop cancer at all or develop it only late in life, thus suggesting a potential modulation of this risk. Epidemiological studies have suggested that other genetic (polymorphisms) and environmental factors (lifestyle) affect penetrance. However, data regarding these associations mainly come from retrospective case-control analyses and the results are likely to be distorted by bias.<h4>Aims</h4>The e-BRAVE (Brca, ReseArch, Virtual, Education) study aims to create a web-based prospective cohort and biological bank of unaffected women carriers of <i>BRCA1/2</i> mutations to investigate the r2025-01-01T00:00:00Z2025 Aug2026-06-03T22:57:37.562Z2026-05-02T03:12:16.8ZS-EPMC124764874078201110.1177/03008916251353420