{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kersch C"],"funding":["Deutsche Gesetzliche Unfallversicherung","Friedrich-Alexander-Universität Erlangen-Nürnberg"],"pagination":["4481-4492"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12477086"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99(11)"],"pubmed_abstract":["Dermal exposure to polycyclic aromatic hydrocarbons (PAHs) and UV irradiation in occupational and environmental settings poses a health risk by inducing skin toxicity, including immunomodulatory effects. This study investigated the effects of benzo[a]pyrene (B[a]P), a well-characterized PAH, at three concentrations (0.04 nM, 4 nM, and 4 µM) and UV irradiation on human monocytic U937 cells, employing both single and combined exposure scenarios. An integrated metabolomics and toxicological approach was utilized to assess cellular responses, with a focus on understanding the immunometabolic effects of these exposures. Our findings revealed that only the highest B[a]P concentration in combination with UV irradiation resulted in significant metabolic dysregulation and impaired cellular function"],"journal":["Archives of toxicology"],"pubmed_title":["Glutaminolysis impairment and immunometabolic dysregulation in U937 cells: Key mechanisms in occupational and environmental skin exposure to UV and benzo[a]pyrene."],"pmcid":["PMC12477086"],"funding_grant_id":["FB 275 B"],"pubmed_authors":["Kaifie A","Schmitz-Spanke S","Masutin V","Kersch C","Alsaleh R","Kuhlmann L"],"additional_accession":[]},"is_claimable":false,"name":"Glutaminolysis impairment and immunometabolic dysregulation in U937 cells: Key mechanisms in occupational and environmental skin exposure to UV and benzo[a]pyrene.","description":"Dermal exposure to polycyclic aromatic hydrocarbons (PAHs) and UV irradiation in occupational and environmental settings poses a health risk by inducing skin toxicity, including immunomodulatory effects. This study investigated the effects of benzo[a]pyrene (B[a]P), a well-characterized PAH, at three concentrations (0.04 nM, 4 nM, and 4 µM) and UV irradiation on human monocytic U937 cells, employing both single and combined exposure scenarios. An integrated metabolomics and toxicological approach was utilized to assess cellular responses, with a focus on understanding the immunometabolic effects of these exposures. Our findings revealed that only the highest B[a]P concentration in combination with UV irradiation resulted in significant metabolic dysregulation and impaired cellular function","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-03T23:18:47.922Z","creation":"2026-05-03T03:10:23.906Z"},"accession":"S-EPMC12477086","cross_references":{"pubmed":["40855183"],"doi":["10.1007/s00204-025-04155-4"]}}