biostudies-literatureUnknown16Zhang BThe extensive use of the herbicide quinclorac has led to significant residues in agricultural soil, posing adverse effects on crop safety and high-quality production. In this study, using the tobacco variety CB-1 as material, we found that oxidizing agent K₂S₂O₈ can significantly reduce quinclorac-induced phytotoxicity symptoms in tobacco. Furthermore, we integrated biochemical methods, metagenomics, metabolomics, and transcriptomics to investigate the effects of K₂S₂O₈ on both quinclorac-contaminated soil and tobacco plants. Soil physicochemical properties analysis showed that the incorporation of K₂S₂O₈-based remediation significantly mitigated the negative effects of quinclorac and largelyFrontiers in microbiology1625585https://www.ebi.ac.uk/biostudies/studies/S-EPMC12477241biostudies-literatureMulti-omics analysis reveals the alleviating effect of oxidation remediation on tobacco quinclorac stress.PMC12477241Cheng CLiu ZLi TXie XGu GChen WZhang NWang FLin XYang TZhong ZZhang BfalseMulti-omics analysis reveals the alleviating effect of oxidation remediation on tobacco quinclorac stress.The extensive use of the herbicide quinclorac has led to significant residues in agricultural soil, posing adverse effects on crop safety and high-quality production. In this study, using the tobacco variety CB-1 as material, we found that oxidizing agent K₂S₂O₈ can significantly reduce quinclorac-induced phytotoxicity symptoms in tobacco. Furthermore, we integrated biochemical methods, metagenomics, metabolomics, and transcriptomics to investigate the effects of K₂S₂O₈ on both quinclorac-contaminated soil and tobacco plants. Soil physicochemical properties analysis showed that the incorporation of K₂S₂O₈-based remediation significantly mitigated the negative effects of quinclorac and largely2025-01-01T00:00:00Z20252026-06-30T03:30:05.901Z2026-06-30T03:22:41.286ZS-EPMC124772414103055210.3389/fmicb.2025.1625585