biostudies-literatureUnknown14(25)Qian JIntegrated Biosensors & BioElectronics LaboratoryShun Hing Institute of Advanced EngineeringChinese University of Hong KongOrganic conducting polymers (CPs) are crucial for wearable bioelectronic devices, including biosensors, offering enhanced sensitivity and adaptability for personalized health monitoring. However, the classical CPs molecular structure limits their development of high-performance wearable biosensors. Among all, pH monitoring related to H⁺ ions is important for managing metabolic disorders, monitoring wound healing and various skin diseases. Here, a novel concept is demonstrated for fabrication of high-performance donor-acceptor (D-A) aniline-based CPs with enhanced sensitivity and stability for wearable biosensors. Density functional theory (DFT) calculations are implemented, using aniline as the acceptor and ortho-substituted aniline derivatives as donors. This approach enables pAdvanced healthcare materialse2501929https://www.ebi.ac.uk/biostudies/studies/S-EPMC12477569biostudies-literatureRational Molecular Design of Aniline-Based Donor-Acceptor Conducting Polymers Enhancing Ionic Molecular Interaction for High-Performance Wearable Bioelectronics.PMC12477569Qian JShi RMak WCZhang LfalseRational Molecular Design of Aniline-Based Donor-Acceptor Conducting Polymers Enhancing Ionic Molecular Interaction for High-Performance Wearable Bioelectronics.Organic conducting polymers (CPs) are crucial for wearable bioelectronic devices, including biosensors, offering enhanced sensitivity and adaptability for personalized health monitoring. However, the classical CPs molecular structure limits their development of high-performance wearable biosensors. Among all, pH monitoring related to H⁺ ions is important for managing metabolic disorders, monitoring wound healing and various skin diseases. Here, a novel concept is demonstrated for fabrication of high-performance donor-acceptor (D-A) aniline-based CPs with enhanced sensitivity and stability for wearable biosensors. Density functional theory (DFT) calculations are implemented, using aniline as the acceptor and ortho-substituted aniline derivatives as donors. This approach enables p2025-01-01T00:00:00Z2025 Sep2026-06-03T23:22:45.465Z2026-05-03T03:11:15.889ZS-EPMC124775694061174410.1002/adhm.202501929