{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Bents SJ"],"funding":["NIAID NIH HHS","Wellcome Trust"],"pubmed_abstract":["The rebound of endemic respiratory viruses following the COVID-19 pandemic was marked by atypical transmission dynamics, with children experiencing increased disease burden and out-of-season epidemics as restrictions relaxed. Here we used serology from a newly developed quantitative multiplex assay to assess the post-pandemic immunity debt, a drop in immunity due to a lack of endemic virus circulation during COVID-19. We assessed age-specific antibody dynamics in Seattle, Washington, US, across a broad range of respiratory viruses, including influenza, respiratory syncytial virus, seasonal coronaviruses, and SARS-CoV-2. We found that respiratory virus immunodynamics differed between individuals <5 years of age and older individuals, with young children experiencing both larger boosts and q"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2025.03.26.25324738"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12478342"],"repository":["biostudies-literature"],"pubmed_title":["Multiplex serology reveals age-specific immunodynamics of endemic respiratory pathogens in the wake of the COVID-19 pandemic."],"pmcid":["PMC12478342"],"funding_grant_id":["75N93021C00015","225001/Z/22/Z"],"pubmed_authors":["Hansen C","Blazevic R","Han P","Bents SJ","Steven-Ayers T","Waghmare A","Andrews C","Kimball L","Englund JA","Boeckh M","Starita L","Adler A","Perofsky A","Wolter N","Prentice R","Moyes J","Martin ET","Krantz EM","Viboud C","von Gottberg A","Cohen C","Hay JA","Maake L"],"additional_accession":[]},"is_claimable":false,"name":"Multiplex serology reveals age-specific immunodynamics of endemic respiratory pathogens in the wake of the COVID-19 pandemic.","description":"The rebound of endemic respiratory viruses following the COVID-19 pandemic was marked by atypical transmission dynamics, with children experiencing increased disease burden and out-of-season epidemics as restrictions relaxed. Here we used serology from a newly developed quantitative multiplex assay to assess the post-pandemic immunity debt, a drop in immunity due to a lack of endemic virus circulation during COVID-19. We assessed age-specific antibody dynamics in Seattle, Washington, US, across a broad range of respiratory viruses, including influenza, respiratory syncytial virus, seasonal coronaviruses, and SARS-CoV-2. We found that respiratory virus immunodynamics differed between individuals <5 years of age and older individuals, with young children experiencing both larger boosts and q","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-07-01T03:09:23.537Z","creation":"2026-07-01T03:07:36.586Z"},"accession":"S-EPMC12478342","cross_references":{"pubmed":["41030929"],"doi":["10.1101/2025.03.26.25324738"]}}