{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Chen YT"],"pubmed_abstract":["<i>Staphylococcus aureus</i> is a leading cause of healthcare-associated pneumonia, contributing significantly to morbidity and mortality worldwide. As a ubiquitous colonizer of the upper respiratory tract, <i>S. aureus</i> must undergo substantial metabolic adaptation to achieve persistent infection in the distinctive microenvironment of the lung. We observed that <i>fumC</i>, which encodes the enzyme that converts fumarate to malate, is highly conserved with low mutation rates in <i>S. aureus</i> isolates from chronic lung infections. Fumarate, a pro-inflammatory metabolite produced by macrophages during infection, is regulated by the host fumarate hydratase (FH) to limit inflammation. Here, we demonstrate that fumarate, which accumulates in the chronically infected lung, is detrimental "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.04.10.647998"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12478345"],"repository":["biostudies-literature"],"pubmed_title":["Regulation of airway fumarate by host and pathogen promotes &lt;i&gt;S. aureus&lt;/i&gt; pneumonia."],"pmcid":["PMC12478345"],"pubmed_authors":["Sridhar SH","Traven A","Monk IR","Wang C","Shah SS","Prince A","Sebra R","Rios G","Drikic M","Liu Z","Stinear TP","Giulieri SG","Bianco C","Tyagi N","Hachani A","Lung TWF","Planet P","Beg AZ","Lewis IA","Fucich D","Wadhwa R","Chen YT","Boyd JM","Henschel H","Riquelme SA","Olivier FAB","Howden BP","Lohia GK"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of airway fumarate by host and pathogen promotes &lt;i&gt;S. aureus&lt;/i&gt; pneumonia.","description":"<i>Staphylococcus aureus</i> is a leading cause of healthcare-associated pneumonia, contributing significantly to morbidity and mortality worldwide. As a ubiquitous colonizer of the upper respiratory tract, <i>S. aureus</i> must undergo substantial metabolic adaptation to achieve persistent infection in the distinctive microenvironment of the lung. We observed that <i>fumC</i>, which encodes the enzyme that converts fumarate to malate, is highly conserved with low mutation rates in <i>S. aureus</i> isolates from chronic lung infections. Fumarate, a pro-inflammatory metabolite produced by macrophages during infection, is regulated by the host fumarate hydratase (FH) to limit inflammation. Here, we demonstrate that fumarate, which accumulates in the chronically infected lung, is detrimental ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-05-05T03:22:24.488Z","creation":"2026-05-05T03:13:21.838Z"},"accession":"S-EPMC12478345","cross_references":{"pubmed":["41030993"],"doi":["10.1101/2025.04.10.647998"]}}