{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Ross CR"],"pubmed_abstract":["Metastasis remains a major cause of cancer mortality. AbstractThis study, expanding upon previous findings in the MMTV-PyMT model, investigated four independent mouse models, representing luminal (MMTV-PyMT, MMTV-Myc), HER2-amplified (MMTV-Her2) and triple negative (C3(1)TAg) breast cancer subtypes. Consistent with previous results, limited evidence for metastasis-associated somatic point mutations was found for all models. We also found that oncogenic drivers significantly influenced the number and size of metastasis-specific copy number variations (MSCNVs), but common driver-independent MSCNVs were rare. Furthermore, analyzing a cohort with varying genetic backgrounds while maintaining a constant oncogenic driver (PyMT) revealed that genetic background profoundly impacts MSCNVs. Transcri"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.01.15.633216"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12478397"],"repository":["biostudies-literature"],"pubmed_title":["Investigating the genomic landscape of mouse models of breast cancer metastasis."],"pmcid":["PMC12478397"],"pubmed_authors":["Ross CR","Qiu T","Hunter KW","Szczepanek K","Sanford J","Pearce L"],"additional_accession":[]},"is_claimable":false,"name":"Investigating the genomic landscape of mouse models of breast cancer metastasis.","description":"Metastasis remains a major cause of cancer mortality. AbstractThis study, expanding upon previous findings in the MMTV-PyMT model, investigated four independent mouse models, representing luminal (MMTV-PyMT, MMTV-Myc), HER2-amplified (MMTV-Her2) and triple negative (C3(1)TAg) breast cancer subtypes. Consistent with previous results, limited evidence for metastasis-associated somatic point mutations was found for all models. We also found that oncogenic drivers significantly influenced the number and size of metastasis-specific copy number variations (MSCNVs), but common driver-independent MSCNVs were rare. Furthermore, analyzing a cohort with varying genetic backgrounds while maintaining a constant oncogenic driver (PyMT) revealed that genetic background profoundly impacts MSCNVs. Transcri","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-05-07T03:23:29.8Z","creation":"2026-05-07T03:12:55.587Z"},"accession":"S-EPMC12478397","cross_references":{"pubmed":["41031038"],"doi":["10.1101/2025.01.15.633216"]}}