{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Littleton ES"],"pubmed_abstract":["Flavonoids are abundant specialized metabolites produced by plants for a range of functions, including pigmentation, hormonal signaling, UV protection, and drought tolerance. We previously showed that flavonoids also influence the circadian clock in <i>Arabidopsis</i> Here, we report that the antioxidant properties of dihydroxy B-ring flavonoids are responsible for influencing the amplitude of the core clock gene luciferase reporter, <i>TOC1:LUC</i> We found the elevated amplitude of <i>TOC1:LUC</i> rhythms correlates with the elevated cellular H<sub>2</sub>O<sub>2</sub> content of flavonoid-deficient seedlings. Moreover, two different chemical approaches to reduce the accumulation of reactive oxygen species rescued the elevated <i>TOC1:LUC</i> amplitude in flavonoid-deficient seedlings, w"],"journal":["Life science alliance"],"pagination":["e202503328"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12479380"],"repository":["biostudies-literature"],"pubmed_title":["Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude in &lt;i&gt;Arabidopsis&lt;/i&gt;."],"pmcid":["PMC12479380"],"pubmed_authors":["Kojima S","Hildreth SB","Littleton ES","Winkel BS"],"additional_accession":[]},"is_claimable":false,"name":"Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude in &lt;i&gt;Arabidopsis&lt;/i&gt;.","description":"Flavonoids are abundant specialized metabolites produced by plants for a range of functions, including pigmentation, hormonal signaling, UV protection, and drought tolerance. We previously showed that flavonoids also influence the circadian clock in <i>Arabidopsis</i> Here, we report that the antioxidant properties of dihydroxy B-ring flavonoids are responsible for influencing the amplitude of the core clock gene luciferase reporter, <i>TOC1:LUC</i> We found the elevated amplitude of <i>TOC1:LUC</i> rhythms correlates with the elevated cellular H<sub>2</sub>O<sub>2</sub> content of flavonoid-deficient seedlings. Moreover, two different chemical approaches to reduce the accumulation of reactive oxygen species rescued the elevated <i>TOC1:LUC</i> amplitude in flavonoid-deficient seedlings, w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-03T23:10:24.072Z","creation":"2026-05-02T03:12:15.951Z"},"accession":"S-EPMC12479380","cross_references":{"pubmed":["41022540"],"doi":["10.26508/lsa.202503328"]}}