{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17"],"submitter":["Ofori E"],"pubmed_abstract":["<h4>Introduction</h4>The apolipoprotein E (<i>APOE</i>) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and cardiovascular disease. This study aimed to investigate the interactive effects of <i>APOE</i> ε4 genotype and cardiovascular risk on the microstructure of the nucleus basalis of Meynert (NBM), a key cholinergic region affected early in AD, using advanced diffusion magnetic resonance imaging.<h4>Methods</h4>This cross-sectional study included 167 cognitively unimpaired older adults from the Arizona <i>APOE</i> Cohort. Participants were stratified by genotype: <i>APOE</i> ε4 non-carriers (<i>N</i> = 83), heterozygous carriers (<i>N</i> = 51), and homozygous carriers (<i>N</i> = 33). Cardiovascular risk was quantified using a composite score calcu"],"journal":["Frontiers in aging neuroscience"],"pagination":["1597127"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12479503"],"repository":["biostudies-literature"],"pubmed_title":["Free-water imaging of the nucleus basalis of Meynert in apolipoprotein E4 carriers."],"pmcid":["PMC12479503"],"pubmed_authors":["Chen K","Ofori E","Braden BB","Su Y","Reiman EM","Caselli RJ"],"additional_accession":[]},"is_claimable":false,"name":"Free-water imaging of the nucleus basalis of Meynert in apolipoprotein E4 carriers.","description":"<h4>Introduction</h4>The apolipoprotein E (<i>APOE</i>) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and cardiovascular disease. This study aimed to investigate the interactive effects of <i>APOE</i> ε4 genotype and cardiovascular risk on the microstructure of the nucleus basalis of Meynert (NBM), a key cholinergic region affected early in AD, using advanced diffusion magnetic resonance imaging.<h4>Methods</h4>This cross-sectional study included 167 cognitively unimpaired older adults from the Arizona <i>APOE</i> Cohort. Participants were stratified by genotype: <i>APOE</i> ε4 non-carriers (<i>N</i> = 83), heterozygous carriers (<i>N</i> = 51), and homozygous carriers (<i>N</i> = 33). Cardiovascular risk was quantified using a composite score calcu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-04T00:10:45.369Z","creation":"2026-05-03T03:12:37.811Z"},"accession":"S-EPMC12479503","cross_references":{"pubmed":["41035826"],"doi":["10.3389/fnagi.2025.1597127"]}}