biostudies-literatureUnknown38(6)Bhadra KUniversity of GenevaAvoidant/Restrictive Food Intake Disorder (ARFID) is a psychiatric condition characterized by extreme food avoidance and limited food intake, leading to nutritional deficiencies, weight loss, and and/or social impairment. Despite its clinical significance, there is a notable lack of research on the neurobiological basis of ARFID. To address this gap, we examined resting-state EEG brain activity in children and adolescents with ARFID, using microstate analysis to capture spatial configurations associated with large-scale brain networks, offering a novel perspective on brain network abnormalities in this population. Eighteen patients with full/subthreshold ARFID (mean age 12.78 ± 3.57) were compared to 18 age- and sex-matched healthy controls (HC) (mean age 14.56 ± 2.85). EEG data were recorBrain topography73https://www.ebi.ac.uk/biostudies/studies/S-EPMC12479596biostudies-literatureEEG Resting-state Microstate Dynamics in Children and Adolescents with Avoidant/Restrictive Food Intake Disorder (ARFID).PMC12479596Bhadra KJanakiram AAHuppi PSBerchio CMarco SMicali NfalseEEG Resting-state Microstate Dynamics in Children and Adolescents with Avoidant/Restrictive Food Intake Disorder (ARFID).Avoidant/Restrictive Food Intake Disorder (ARFID) is a psychiatric condition characterized by extreme food avoidance and limited food intake, leading to nutritional deficiencies, weight loss, and and/or social impairment. Despite its clinical significance, there is a notable lack of research on the neurobiological basis of ARFID. To address this gap, we examined resting-state EEG brain activity in children and adolescents with ARFID, using microstate analysis to capture spatial configurations associated with large-scale brain networks, offering a novel perspective on brain network abnormalities in this population. Eighteen patients with full/subthreshold ARFID (mean age 12.78 ± 3.57) were compared to 18 age- and sex-matched healthy controls (HC) (mean age 14.56 ± 2.85). EEG data were recor2025-01-01T00:00:00Z2025 Sep2026-06-06T13:36:17.944Z2026-05-31T03:07:49.079ZS-EPMC124795964102342310.1007/s10548-025-01149-4