{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Almgrami RT"],"funding":["Postdoctoral Fellowship Program","Medical Science and Technology Research Project of Henan Province","Key Special Project for International Science and Technology Innovation Cooperation between Governments under the National Key R&amp;D Program","Postdoctoral Fellowship Program (Grade C)","National Natural Science Foundation of China-General Project","Key Special Project for International Science and Technology Innovation Cooperation between Governments under the National Key R&D Program","National Natural Science Foundation of China–General Project","National Natural Science Foundation of China Joint Fund Key Support Project"],"pagination":["319"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12480184"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(10)"],"pubmed_abstract":["<h4>Background</h4>Metastatic lung carcinoma poses considerable treatment difficulties. It exhibits cellular characteristics that differ from those of early-stage cancer. Immunotherapy demonstrates enhanced hope for patients with advanced and metastatic lung cancer. Tumor-associated macrophages (TAMs) may be a contributing factor that diminishes the effectiveness of immunotherapy. Secreted phosphoprotein 1 (SPP1)<sup>+ </sup>TAMs are considered to possess immunosuppressive characteristics, as their interaction with CD8<sup>+</sup> T lymphocytes results in the exhaustion of these cells.<h4>Methods</h4>We analyzed single-cell RNA sequencing datasets of lung cancer metastases in order to examine the development of brain metastatic tumors. Furthermore, the cell-cell interactions between SPP1<s"],"journal":["Cancer immunology, immunotherapy : CII"],"pubmed_title":["Single-cell transcriptomic analyses provide insights into SPP1&lt;sup&gt;+&lt;/sup&gt; TAM-mediated immune suppression and CD8&lt;sup&gt;+&lt;/sup&gt; T cell dysfunction in lung cancer."],"pmcid":["PMC12480184"],"funding_grant_id":["252102311163","2022YFE0141000","GZC20232435","U24A20734","82272873"],"pubmed_authors":["Liu J","Zhang T","Almgrami RT","Zhao Q","You M","Zhang Y"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptomic analyses provide insights into SPP1&lt;sup&gt;+&lt;/sup&gt; TAM-mediated immune suppression and CD8&lt;sup&gt;+&lt;/sup&gt; T cell dysfunction in lung cancer.","description":"<h4>Background</h4>Metastatic lung carcinoma poses considerable treatment difficulties. It exhibits cellular characteristics that differ from those of early-stage cancer. Immunotherapy demonstrates enhanced hope for patients with advanced and metastatic lung cancer. Tumor-associated macrophages (TAMs) may be a contributing factor that diminishes the effectiveness of immunotherapy. Secreted phosphoprotein 1 (SPP1)<sup>+ </sup>TAMs are considered to possess immunosuppressive characteristics, as their interaction with CD8<sup>+</sup> T lymphocytes results in the exhaustion of these cells.<h4>Methods</h4>We analyzed single-cell RNA sequencing datasets of lung cancer metastases in order to examine the development of brain metastatic tumors. Furthermore, the cell-cell interactions between SPP1<s","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-04T12:18:18.793Z","creation":"2026-05-09T03:08:01.156Z"},"accession":"S-EPMC12480184","cross_references":{"pubmed":["41021043"],"doi":["10.1007/s00262-025-04180-3"]}}