{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang L"],"funding":["Scientific Research Foundation for Returned Scholars of Tongji Hospital","Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province","Jiangsu Province Basic Research Program Natural Science Foundation","National Natural Science Foundation of China","the Key Program of Basic Science (Natural Science) of Jiangsu Province","Scientific Research Fund of Tongji Hospital"],"pagination":["33541"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12480698"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Colorectal cancer (CRC) remains a major cause of cancer-related mortality worldwide, especially in advanced and metastatic stages where treatment options are limited. HJ-4, a novel piperine derivative, demonstrated strong tumor-selective inhibition. Within safe concentrations (cell viability > 85%), HJ-4 dose-dependently suppressed colony formation and DNA synthesis in CRC cells, showing potent anti-proliferative effects. It also significantly inhibited cell adhesion, wound healing, and invasion, indicating robust anti-migration and anti-invasion properties. In vivo, the CAM model confirmed that HJ-4 reduced both tumor volume and angiogenesis. Mechanistically, HJ-4 activated the p53-dependent apoptosis pathway while suppressing the Wnt/β-catenin axis and E2F transcriptional activity, effec"],"journal":["Scientific reports"],"pubmed_title":["HJ-4, a novel piperine derivative, inhibits tumor growth and angiogenesis via p53 activation and oncogenic pathway inhibition in colorectal cancer models."],"pmcid":["PMC12480698"],"funding_grant_id":["22KJA350001","CXPJJH123003-027","2023A09","82273167","2022hgry021","BK20220063"],"pubmed_authors":["Zou X","Li X","Hu Z","Wang D","Zhang X","Xu D","Liu B","Zhang L","Liu S","Wang X","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"HJ-4, a novel piperine derivative, inhibits tumor growth and angiogenesis via p53 activation and oncogenic pathway inhibition in colorectal cancer models.","description":"Colorectal cancer (CRC) remains a major cause of cancer-related mortality worldwide, especially in advanced and metastatic stages where treatment options are limited. HJ-4, a novel piperine derivative, demonstrated strong tumor-selective inhibition. Within safe concentrations (cell viability > 85%), HJ-4 dose-dependently suppressed colony formation and DNA synthesis in CRC cells, showing potent anti-proliferative effects. It also significantly inhibited cell adhesion, wound healing, and invasion, indicating robust anti-migration and anti-invasion properties. In vivo, the CAM model confirmed that HJ-4 reduced both tumor volume and angiogenesis. Mechanistically, HJ-4 activated the p53-dependent apoptosis pathway while suppressing the Wnt/β-catenin axis and E2F transcriptional activity, effec","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T23:28:56.14Z","creation":"2026-05-03T03:11:55.62Z"},"accession":"S-EPMC12480698","cross_references":{"pubmed":["41023097"],"doi":["10.1038/s41598-025-18290-6"]}}