{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["De Tymowski C"],"pubmed_abstract":["High-density lipoproteins (HDL) are nanoparticles that enable the reverse transport of cholesterol and have multiple endothelioprotective properties that may play a role in sepsis, where HDL-cholesterol (HDL-C) concentrations typically plummet, which is strongly linked to poor outcomes. While HDL has the capacity to capture and eliminate lipopolysaccharides (LPS), which may explain this decrease in HDL-C concentration, this effect is less clear for Gram-positive bacteria via binding to lipoteichoic acid (LTA). The aim of this study is to determine whether the type of bacteria influences HDL-C concentrations in septic patients. This was a prospective, observational, single-center study of septic patients hospitalized in the intensive care unit (ICU). Patients were stratified into three grou"],"journal":["Scientific reports"],"pagination":["33556"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12480970"],"repository":["biostudies-literature"],"pubmed_title":["Impact of the type of bacteria on high-density lipoprotein cholesterol level during sepsis."],"pmcid":["PMC12480970"],"pubmed_authors":["Atchade E","Meilhac O","Snauwaert A","De Tymowski C","Tanaka S","Robert T","Lortat-Jacob B","Stern J","Boutten A","Zappella N","Montravers P"],"additional_accession":[]},"is_claimable":false,"name":"Impact of the type of bacteria on high-density lipoprotein cholesterol level during sepsis.","description":"High-density lipoproteins (HDL) are nanoparticles that enable the reverse transport of cholesterol and have multiple endothelioprotective properties that may play a role in sepsis, where HDL-cholesterol (HDL-C) concentrations typically plummet, which is strongly linked to poor outcomes. While HDL has the capacity to capture and eliminate lipopolysaccharides (LPS), which may explain this decrease in HDL-C concentration, this effect is less clear for Gram-positive bacteria via binding to lipoteichoic acid (LTA). The aim of this study is to determine whether the type of bacteria influences HDL-C concentrations in septic patients. This was a prospective, observational, single-center study of septic patients hospitalized in the intensive care unit (ICU). Patients were stratified into three grou","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T23:22:33.157Z","creation":"2026-05-03T03:11:12.468Z"},"accession":"S-EPMC12480970","cross_references":{"pubmed":["41023060"],"doi":["10.1038/s41598-025-18473-1"]}}