biostudies-literatureUnknown15(1)De Tymowski CHigh-density lipoproteins (HDL) are nanoparticles that enable the reverse transport of cholesterol and have multiple endothelioprotective properties that may play a role in sepsis, where HDL-cholesterol (HDL-C) concentrations typically plummet, which is strongly linked to poor outcomes. While HDL has the capacity to capture and eliminate lipopolysaccharides (LPS), which may explain this decrease in HDL-C concentration, this effect is less clear for Gram-positive bacteria via binding to lipoteichoic acid (LTA). The aim of this study is to determine whether the type of bacteria influences HDL-C concentrations in septic patients. This was a prospective, observational, single-center study of septic patients hospitalized in the intensive care unit (ICU). Patients were stratified into three grouScientific reports33556https://www.ebi.ac.uk/biostudies/studies/S-EPMC12480970biostudies-literatureImpact of the type of bacteria on high-density lipoprotein cholesterol level during sepsis.PMC12480970Atchade EMeilhac OSnauwaert ADe Tymowski CTanaka SRobert TLortat-Jacob BStern JBoutten AZappella NMontravers PfalseImpact of the type of bacteria on high-density lipoprotein cholesterol level during sepsis.High-density lipoproteins (HDL) are nanoparticles that enable the reverse transport of cholesterol and have multiple endothelioprotective properties that may play a role in sepsis, where HDL-cholesterol (HDL-C) concentrations typically plummet, which is strongly linked to poor outcomes. While HDL has the capacity to capture and eliminate lipopolysaccharides (LPS), which may explain this decrease in HDL-C concentration, this effect is less clear for Gram-positive bacteria via binding to lipoteichoic acid (LTA). The aim of this study is to determine whether the type of bacteria influences HDL-C concentrations in septic patients. This was a prospective, observational, single-center study of septic patients hospitalized in the intensive care unit (ICU). Patients were stratified into three grou2025-01-01T00:00:00Z2025 Sep2026-06-03T23:22:33.157Z2026-05-03T03:11:12.468ZS-EPMC124809704102306010.1038/s41598-025-18473-1