biostudies-literatureUnknown30(1)Abebe Y<h4>Background</h4>Puerperal sepsis is a leading cause of maternal morbidity and is responsible for nearly one-fifth of maternal deaths worldwide. In Ethiopia, it remains a significant contributor to maternal mortality; however, a comprehensive understanding of its determinants is still lacking. Therefore, the aim of this systematic review and meta-analysis is to estimate the pooled prevalence of puerperal sepsis and to identify its determinant factors in Ethiopia, thereby providing comprehensive and up-to-date evidence to inform maternal health interventions.<h4>Methods</h4>The review was conducted in accordance with the Joanna Briggs Institute methodological guidance for systematic reviews and meta-analyses and reported following the Preferred Reporting Items for Systematic Reviews and MEuropean journal of medical research915https://www.ebi.ac.uk/biostudies/studies/S-EPMC12481748biostudies-literatureBurden and determinants of puerperal sepsis in Ethiopia: a systematic review and meta-analysis.PMC12481748Gashaw ADemissie RAbebe YfalseBurden and determinants of puerperal sepsis in Ethiopia: a systematic review and meta-analysis.<h4>Background</h4>Puerperal sepsis is a leading cause of maternal morbidity and is responsible for nearly one-fifth of maternal deaths worldwide. In Ethiopia, it remains a significant contributor to maternal mortality; however, a comprehensive understanding of its determinants is still lacking. Therefore, the aim of this systematic review and meta-analysis is to estimate the pooled prevalence of puerperal sepsis and to identify its determinant factors in Ethiopia, thereby providing comprehensive and up-to-date evidence to inform maternal health interventions.<h4>Methods</h4>The review was conducted in accordance with the Joanna Briggs Institute methodological guidance for systematic reviews and meta-analyses and reported following the Preferred Reporting Items for Systematic Reviews and M2025-01-01T00:00:00Z2025 Sep2026-06-03T23:28:28.359Z2026-05-03T03:11:44.687ZS-EPMC124817484102421710.1186/s40001-025-03138-6