{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chung H"],"funding":["NIDCD NIH HHS","NIH HHS"],"pagination":["58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12482115"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>Restricted and repetitive behaviors (RRB) are core features of autism but are also observed in typical development. Our understanding of the neural underpinnings of RRBs is limited. Given that excitation-inhibition (E/I) balance may underlie RRBs, we aimed to evaluate the relationship between aperiodic exponent (as a proxy of E/I balance) and changes in RRBs over time in infants with and without elevated likelihood of autism.<h4>Methods</h4>Resting-state EEG data were collected from 12-to-14-month-old infants and aperiodic exponent was calculated. Parent-reported RRBs were obtained using the Repetitive Behavior Scale-Revised questionnaire to measure the severity and change in RRBs from 12-to-36 months. Multiple linear regressions were conducted to assess relationships be"],"journal":["Journal of neurodevelopmental disorders"],"pubmed_title":["The association between infant EEG aperiodic exponent and the trajectory of restricted and repetitive behaviors for toddlers with and without autism."],"pmcid":["PMC12482115"],"funding_grant_id":["R01-DC010290","R03 DC007983","K23DC07983","R01 DC010290"],"pubmed_authors":["Job Said A","Wilkinson CL","Chung H","Tager-Flusberg H","Nelson CA"],"additional_accession":[]},"is_claimable":false,"name":"The association between infant EEG aperiodic exponent and the trajectory of restricted and repetitive behaviors for toddlers with and without autism.","description":"<h4>Background</h4>Restricted and repetitive behaviors (RRB) are core features of autism but are also observed in typical development. Our understanding of the neural underpinnings of RRBs is limited. Given that excitation-inhibition (E/I) balance may underlie RRBs, we aimed to evaluate the relationship between aperiodic exponent (as a proxy of E/I balance) and changes in RRBs over time in infants with and without elevated likelihood of autism.<h4>Methods</h4>Resting-state EEG data were collected from 12-to-14-month-old infants and aperiodic exponent was calculated. Parent-reported RRBs were obtained using the Repetitive Behavior Scale-Revised questionnaire to measure the severity and change in RRBs from 12-to-36 months. Multiple linear regressions were conducted to assess relationships be","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-04T05:05:45.549Z","creation":"2026-06-03T03:07:45.977Z"},"accession":"S-EPMC12482115","cross_references":{"pubmed":["41023786"],"doi":["10.1186/s11689-025-09651-3"]}}