{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["NIDCD NIH HHS","NCI NIH HHS"],"pagination":["2156-2170.e6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12482137"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(11)"],"pubmed_abstract":["To enable early detection of pancreatic cancer from precancerous lesions, we analyze proteins and glycoproteins from 64 intraductal papillary mucinous neoplasms (IPMNs), 55 cyst fluid samples, 104 pancreatic ductal adenocarcinomas (PDACs), and various types of normal samples using mass spectrometry. High-grade IPMNs show enrichment of glycosylation level and tumor progression pathways compared to low-grade lesions. High-grade IPMN associated proteins, such as PLOD3, IRS2, LGALS9, and Trop-2, are identified and validated using immunolabeling and laser microdissection. Some high-grade associated proteins are also detected in pancreatic cyst fluids, which allows us to link proteins and glycoproteins expressed in neoplastic cells to clinically accessible biospecimens. Altered glycosylation lev"],"journal":["Cancer cell"],"pubmed_title":["Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct patterns and potential markers of progression."],"pmcid":["PMC12482137"],"funding_grant_id":["U24 CA210985","R01 DC000633","U01 CA274514","U24 CA271079"],"pubmed_authors":["Goggins MG","Jiao L","Goodman D","Mino-Kenudson M","Adsay NV","Zhang H","Ohtsuka T","Luchini C","Paulino J","Wood LD","Kim GE","Wang Y","Woo J","Maker AV","Chen L","Matthaei H","Lih TM","Sun Z","Lee JW","Hruban RH","Roberts NJ","Scarpa A","Furukawa T","Hozaka Y","Pfluger MJ"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct patterns and potential markers of progression.","description":"To enable early detection of pancreatic cancer from precancerous lesions, we analyze proteins and glycoproteins from 64 intraductal papillary mucinous neoplasms (IPMNs), 55 cyst fluid samples, 104 pancreatic ductal adenocarcinomas (PDACs), and various types of normal samples using mass spectrometry. High-grade IPMNs show enrichment of glycosylation level and tumor progression pathways compared to low-grade lesions. High-grade IPMN associated proteins, such as PLOD3, IRS2, LGALS9, and Trop-2, are identified and validated using immunolabeling and laser microdissection. Some high-grade associated proteins are also detected in pancreatic cyst fluids, which allows us to link proteins and glycoproteins expressed in neoplastic cells to clinically accessible biospecimens. Altered glycosylation lev","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T13:36:16.776Z","creation":"2026-05-31T03:07:48.892Z"},"accession":"S-EPMC12482137","cross_references":{"pubmed":["40882635"],"doi":["10.1016/j.ccell.2025.08.001"]}}