biostudies-literatureGomez RJFundação para a Ciência e a TecnologiaBrazilian National Council for Scientific and Technology Development of BrazilFundação de Amparo à Pesquisa do Estado de São Paulo738https://www.ebi.ac.uk/biostudies/studies/S-EPMC12482374biostudies-literatureUnknown25(1)<h4>Aim</h4>We investigated the impact of abrupt interruption, imposed by COVID-19, and subsequent resumption of regular practice of a combined exercise training program on protein, renal profile, and physical functional capacity in physically active older adults before the pandemic.<h4>Methods</h4>Thirty-five volunteers (mean age 64.36 ± 19.43 years) participated, with data collected before the COVID-19 pandemic (PRE), 12 months after social isolation (PAN, detraining period), and 10 months after returning to regular exercise (POST).<h4>Results</h4>In the POST period, both older women (n = 26) and men (n = 9) exhibited higher serum levels of albumin and total protein (p < 0.0001 for albumin and total proteins in older women group; p = 0.0033 for albumin and p = 0.0002 for total proteins iBMC geriatricsMitigation of detraining effects: physical activity improves protein profile and physical function of aged amid COVID-19.PMC124823742019/14115-0CEECINST/00077/2021PQ-2 #305008/2022-6da Silva FCAmirato GRRibeiro APBachi ALLSilva BRRossi MBotelho ARda Silva Nali LHde Almeida MSFurtado GEMonteiro FRGomez RJdo Amaral JBNardy APaixao Vde Paula Vieira RSantos CAFfalseMitigation of detraining effects: physical activity improves protein profile and physical function of aged amid COVID-19.<h4>Aim</h4>We investigated the impact of abrupt interruption, imposed by COVID-19, and subsequent resumption of regular practice of a combined exercise training program on protein, renal profile, and physical functional capacity in physically active older adults before the pandemic.<h4>Methods</h4>Thirty-five volunteers (mean age 64.36 ± 19.43 years) participated, with data collected before the COVID-19 pandemic (PRE), 12 months after social isolation (PAN, detraining period), and 10 months after returning to regular exercise (POST).<h4>Results</h4>In the POST period, both older women (n = 26) and men (n = 9) exhibited higher serum levels of albumin and total protein (p < 0.0001 for albumin and total proteins in older women group; p = 0.0033 for albumin and p = 0.0002 for total proteins i2025-01-01T00:00:00Z2025 Sep2026-06-04T01:33:04.633Z2026-05-03T03:14:11.931ZS-EPMC124823744102387710.1186/s12877-025-06347-0