biostudies-literatureMorrison CAustralian Society of Anaesthetists384https://www.ebi.ac.uk/biostudies/studies/S-EPMC12482444biostudies-literatureUnknown26(1)<h4>Background</h4>The pericapsular nerve group (PENG) block is a novel regional technique for hip analgesia. Traditionally, intrathecal morphine has been administered for analgesia in hip fracture surgery. Compared with intrathecal morphine, the PENG block may provide superior or equivalent pain score reduction with a more favourable side effect profile and superior patient satisfaction.<h4>Methods</h4>This is a multicentre blinded randomised controlled trial (RCT) that is being conducted at present at two large teaching institutions in Australia. The pericapsular nerve group block (PENG block) shall be compared to low-dose intrathecal morphine for analgesic effect in elective total Hip arthroplasty via the direct anterior approach. Primary outcome shall be dynamic pain score evaluation aTrialsThe utility of pericapsular nerve group (PENG) block versus intrathecal morphine for postoperative analgesia in anterior approach total hip arthroplasty: a multicentre triple blinded randomised controlled trial protocol.PMC12482444Jackson Rees Research GrantAlford HChin KJKroon HMMorrison CCheok TLin DYBrown BCalvert MNikos DLock Bde Prinse LJaarsma RSaville GMay NfalseThe utility of pericapsular nerve group (PENG) block versus intrathecal morphine for postoperative analgesia in anterior approach total hip arthroplasty: a multicentre triple blinded randomised controlled trial protocol.<h4>Background</h4>The pericapsular nerve group (PENG) block is a novel regional technique for hip analgesia. Traditionally, intrathecal morphine has been administered for analgesia in hip fracture surgery. Compared with intrathecal morphine, the PENG block may provide superior or equivalent pain score reduction with a more favourable side effect profile and superior patient satisfaction.<h4>Methods</h4>This is a multicentre blinded randomised controlled trial (RCT) that is being conducted at present at two large teaching institutions in Australia. The pericapsular nerve group block (PENG block) shall be compared to low-dose intrathecal morphine for analgesic effect in elective total Hip arthroplasty via the direct anterior approach. Primary outcome shall be dynamic pain score evaluation a2025-01-01T00:00:00Z2025 Sep2026-06-04T00:30:57.135Z2026-05-03T03:12:24.267ZS-EPMC124824444102410910.1186/s13063-025-09127-8