{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(1)"],"submitter":["Kumano M"],"pubmed_abstract":["<h4>Background</h4>Drug-induced acute interstitial nephritis (DI-AIN) is the most common type of AIN. DI-AIN occurs when medications trigger a T cell-mediated immune response that promotes tubulitis and interstitial inflammation with eosinophils, often resulting in acute kidney injury (AKI) with nephromegaly. Recently, prolonged use of cyclin-dependent kinase (CDK) 4/6 inhibitors, as oral molecular-targeted drugs for breast cancer, was identified as a cause of AKI, including AIN and acute tubular necrosis (ATN). To date, there have been no reported cases of AIN associated with the use of abemaciclib, a CDK4/6 inhibitor.<h4>Case presentation</h4>A 66-year-old Japanese woman presented with persistent diarrhea and nausea shortly after the initiation of abemaciclib for breast cancer and was su"],"journal":["BMC nephrology"],"pagination":["543"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12482685"],"repository":["biostudies-literature"],"pubmed_title":["Abemaciclib-associated acute interstitial nephritis successfully treated with glucocorticoids: a case report and literature review."],"pmcid":["PMC12482685"],"pubmed_authors":["Kumano M","Yanagidani H","Yoshida M","Teragawa Y","Maeoka Y","Takahashi A","Masaki T"],"additional_accession":[]},"is_claimable":false,"name":"Abemaciclib-associated acute interstitial nephritis successfully treated with glucocorticoids: a case report and literature review.","description":"<h4>Background</h4>Drug-induced acute interstitial nephritis (DI-AIN) is the most common type of AIN. DI-AIN occurs when medications trigger a T cell-mediated immune response that promotes tubulitis and interstitial inflammation with eosinophils, often resulting in acute kidney injury (AKI) with nephromegaly. Recently, prolonged use of cyclin-dependent kinase (CDK) 4/6 inhibitors, as oral molecular-targeted drugs for breast cancer, was identified as a cause of AKI, including AIN and acute tubular necrosis (ATN). To date, there have been no reported cases of AIN associated with the use of abemaciclib, a CDK4/6 inhibitor.<h4>Case presentation</h4>A 66-year-old Japanese woman presented with persistent diarrhea and nausea shortly after the initiation of abemaciclib for breast cancer and was su","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-04T00:17:47.588Z","creation":"2026-05-03T03:12:16.159Z"},"accession":"S-EPMC12482685","cross_references":{"pubmed":["41023873"],"doi":["10.1186/s12882-025-04442-3"]}}