{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shneider BL"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","NIEHS NIH HHS","NIMHD NIH HHS","NCI NIH HHS"],"pagination":["e0796"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12483069"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(10)"],"pubmed_abstract":["<h4>Background</h4>Pediatric cholestatic liver diseases can be characterized by rapidly progressive fibrosis. A multicenter cross-sectional analysis of vibration-controlled elastography in biliary atresia (BA), alpha-1 antitrypsin deficiency (A1AT), and Alagille syndrome (ALGS) was leveraged to interrogate the plasma proteome relative to liver stiffness measurements (LSM).<h4>Methods</h4>Slow off-rate modified aptamer scanning profiling of >7000 proteins in plasma from 187 children with BA (n=93), A1AT (n=31), ALGS (n=46), and healthy pediatric controls (n=17) was performed, and correlations with LSM were undertaken.<h4>Results</h4>There was an abundance of LSM correlated proteins (BA n=2720, A1AT n=694, ALGS n=5968). Interestingly, a distinct plasma proteome was found in ALGS relative to "],"journal":["Hepatology communications"],"pubmed_title":["Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition."],"pmcid":["PMC12483069"],"funding_grant_id":["U01 DK062497","U01 DK062453","U01 DK062470","U01 DK062481","U01 DK103149","U24 DK062456","P30 ES030285","U01 DK062436","U01 DK084575","U01 DK084538","U01 DK062456","U01 DK062500","UM1 TR004399","P30 CA125123","U01 DK084536","U01 DK062466","P50 MD015496","P42 ES027725","U01 DK103140","K08 CA245220"],"pubmed_authors":["Emamaullee J","Grimm SL","Hsu E","Horslen SP","Wang KS","Coarfa C","Shneider BL","Kriegmeier A","Childhood Liver Disease Research Network","Bezerra JA","Schraw J","Lupo PJ","Kanchi RS","Magee JC","Barbetta A","Sokol RJ","Molleston JP","Loomes KM","Rosenthal P","Kohli R","Jensen MK","Devaraj S","Karpen SJ"],"additional_accession":[]},"is_claimable":false,"name":"Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition.","description":"<h4>Background</h4>Pediatric cholestatic liver diseases can be characterized by rapidly progressive fibrosis. A multicenter cross-sectional analysis of vibration-controlled elastography in biliary atresia (BA), alpha-1 antitrypsin deficiency (A1AT), and Alagille syndrome (ALGS) was leveraged to interrogate the plasma proteome relative to liver stiffness measurements (LSM).<h4>Methods</h4>Slow off-rate modified aptamer scanning profiling of >7000 proteins in plasma from 187 children with BA (n=93), A1AT (n=31), ALGS (n=46), and healthy pediatric controls (n=17) was performed, and correlations with LSM were undertaken.<h4>Results</h4>There was an abundance of LSM correlated proteins (BA n=2720, A1AT n=694, ALGS n=5968). Interestingly, a distinct plasma proteome was found in ALGS relative to ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-15T06:09:19.173Z","creation":"2026-06-15T03:08:35.509Z"},"accession":"S-EPMC12483069","cross_references":{"pubmed":["41021277"],"doi":["10.1097/HC9.0000000000000796"]}}