biostudies-literatureUnknown20(9)Gimena Munoz R<h4>Background</h4>Frailty is a highly prevalent syndrome in patients with advanced age and chronic diseases, and it is associated with atherothrombotic pathologies, suggesting a procoagulant state in these patients. Circulating microvesicles (cMVs), are small phospholipid-rich vesicles, which have been shown to participate in atherothrombotic onset and progression. We aim to analyze frailty in patients with advanced chronic kidney disease (CKD), and to determine the role of microvesicles in this population.<h4>Materials and methods</h4>We conducted a prospective cohort study with 85 patients with advanced CKD. Our main objective was to evaluate frailty and its novel association with circulating microvesicles in advanced CKD. To define frailty, Fried's five criteria were used and we obtainPloS onee0332653https://www.ebi.ac.uk/biostudies/studies/S-EPMC12483209biostudies-literatureAssessment of frailty in patients with advanced chronic kidney disease, and the role of microvesicles: A single-center study.PMC12483209Carracedo JS Waikar SRamirez-Chamond RValera Arevalo GRodriguez San Pedro MDMRodriguez Puyol DGimena Munoz RMartinez Miguel PArevalo Serrano JPerez Fernandez MfalseAssessment of frailty in patients with advanced chronic kidney disease, and the role of microvesicles: A single-center study.<h4>Background</h4>Frailty is a highly prevalent syndrome in patients with advanced age and chronic diseases, and it is associated with atherothrombotic pathologies, suggesting a procoagulant state in these patients. Circulating microvesicles (cMVs), are small phospholipid-rich vesicles, which have been shown to participate in atherothrombotic onset and progression. We aim to analyze frailty in patients with advanced chronic kidney disease (CKD), and to determine the role of microvesicles in this population.<h4>Materials and methods</h4>We conducted a prospective cohort study with 85 patients with advanced CKD. Our main objective was to evaluate frailty and its novel association with circulating microvesicles in advanced CKD. To define frailty, Fried's five criteria were used and we obtain2025-01-01T00:00:00Z20252026-06-04T00:17:40.901Z2026-05-03T03:12:13.049ZS-EPMC124832094102674710.1371/journal.pone.0332653